NMR diffusion and relaxation study of drug-protein interaction
文献类型：期刊论文
| 作者 | Luo, RS; Liu, ML; Mao, XA |
| 刊名 | SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
 |
| 出版日期 | 1999-08-01 |
| 卷号 | 55期号:9页码:1897-1901 |
| 关键词 | salicylate human serum albumin interaction nuclear magnetic resonance self-diffusion coefficient relaxation rates |
| 英文摘要 | In this work, NMR diffusion and relaxation measurements are applied to the study of the interaction between the anti-inflammatory drug salicylate and the human serum albumin (HSA) in solutions. The self-diffusion coefficients and the spin-lattice relaxation rates of salicylate are measured as a function of the concentration. The dissociation constant, K-d, for drug/HSA complexes and the number of binding sites, n, are evaluated. (C) 1999 Elsevier Science B.V. AU rights reserved. |
| WOS标题词 | Science & Technology ; Technology |
| 类目[WOS] | Spectroscopy |
| 研究领域[WOS] | Spectroscopy |
| 关键词[WOS] | HUMAN SERUM-ALBUMIN ; NUCLEAR-MAGNETIC-RESONANCE ; ANTIINFLAMMATORY DRUGS ; BINDING ; IBUPROFEN ; AFFINITY ; SITE ; CHROMATOGRAPHY ; SPECTROSCOPY ; ENANTIOMERS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000081491400019 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8445]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | Chinese Acad Sci, Lab Magnet Resonance & Atom Mol Phys, Wuhan Inst Phys & Math, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Luo, RS,Liu, ML,Mao, XA. NMR diffusion and relaxation study of drug-protein interaction[J]. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,1999,55(9):1897-1901. |
| APA | Luo, RS,Liu, ML,&Mao, XA.(1999).NMR diffusion and relaxation study of drug-protein interaction.SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,55(9),1897-1901. |
| MLA | Luo, RS,et al."NMR diffusion and relaxation study of drug-protein interaction".SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY 55.9(1999):1897-1901. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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