Liver-targeting macromolecular MRI contrast agents
文献类型：期刊论文
| 作者 | Yang, GP; Zhuo, RX; Xu, MY; Li, LY; Tang, YF |
| 刊名 | SCIENCE IN CHINA SERIES B-CHEMISTRY
 |
| 出版日期 | 2001-08-01 |
| 卷号 | 44期号:4页码:344-352 |
| 关键词 | polyaspartamide gadolinium complexes magnetic resonance imaging (MRI) relaxivity liver-targeting |
| 英文摘要 | Macromolecular ligands with liver-targeting group (pyridoxamine, PM) PHEA-DTPA-PM and PAEA-DTPA-PM were prepared by the incorporation of different amount of diethylenetriaminepentaacetic acid monopyridoxamine group (DTPA-PM) into poly-alpha, beta-[N-(2-hydroxyethyl)-L-aspartamide] (PHEA) and poly-alpha, beta-[N-(2-aminoethyl)-L-aspartamide] (PAEA). The macromolecular ligands thus obtained were further complexed with gadolinium chloride to give macromolecular MRI contrast agents with different Gd(III) contents. These macromolecular ligands and their gadolinium complexes were characterized by H-1 NMR, IR, UV and elementary analysis. Relaxivity studies showed that these polyaspartamide gadolinium complexes possess higher relaxation effectiveness than that of the clinically used Gd-DTPA. Magnetic resonance imaging of the liver in rats and experimental data of biodistribution in mice indicate that these macromolecular MR] contrast agents containing pyridoxamine exhibit liver-targeting property. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | COMPLEXES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171890600002 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8605]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Univ, Dept Chem, Minist Educ, Lab Biomed Polymer Mat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, GP,Zhuo, RX,Xu, MY,et al. Liver-targeting macromolecular MRI contrast agents[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2001,44(4):344-352. |
| APA | Yang, GP,Zhuo, RX,Xu, MY,Li, LY,&Tang, YF.(2001).Liver-targeting macromolecular MRI contrast agents.SCIENCE IN CHINA SERIES B-CHEMISTRY,44(4),344-352. |
| MLA | Yang, GP,et al."Liver-targeting macromolecular MRI contrast agents".SCIENCE IN CHINA SERIES B-CHEMISTRY 44.4(2001):344-352. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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