Synthesis, relaxivity and MRI enhancement of linear oligo-Gd(III) complexes with poly (DTPA-ester) ligands derived from amino acids
文献类型：期刊论文
| 作者 | Yu, KC; Wang, XB; Ye, CH; Li, LY; Liu, ML; Zhuo, RX |
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2001-08-01 |
| 卷号 | 19期号:8页码:788-793 |
| 关键词 | magnetic resonance imaging ( MRI) contrast agents oligomeric Gd(III) complex polyester derived from amino acids relaxivity enhancement |
| 英文摘要 | Six linear oligo-DTPA-ester Gd(HI) complexes being used for potential MRI contrast agents were synthesized from amino acids and characterized. Their longitudinal relaxation rates were measured. One of them, the phenylalanine derivative, with high relaxivity, was chosen for the acute toxicity and T-1-weighted imaging test. The results indicated that there was no obvious toxicity for this new oligomeric Gd(M) complex, and it exhibits the highly enhanced MRI signal intensity and the increasing signal duration in the liver time compared to Gd-DTPA. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Multidisciplinary |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | CONTRAST AGENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000171453400013 |
| 公开日期 | 2015-12-01 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8607]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Hubei, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China 3.Wuhan Univ, Coll Chem & Mol Sci, Educ Minist China, Key Lab Biomed Polymer Mat, Wuhan 430072, Hubei, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, KC,Wang, XB,Ye, CH,et al. Synthesis, relaxivity and MRI enhancement of linear oligo-Gd(III) complexes with poly (DTPA-ester) ligands derived from amino acids[J]. CHINESE JOURNAL OF CHEMISTRY,2001,19(8):788-793. |
| APA | Yu, KC,Wang, XB,Ye, CH,Li, LY,Liu, ML,&Zhuo, RX.(2001).Synthesis, relaxivity and MRI enhancement of linear oligo-Gd(III) complexes with poly (DTPA-ester) ligands derived from amino acids.CHINESE JOURNAL OF CHEMISTRY,19(8),788-793. |
| MLA | Yu, KC,et al."Synthesis, relaxivity and MRI enhancement of linear oligo-Gd(III) complexes with poly (DTPA-ester) ligands derived from amino acids".CHINESE JOURNAL OF CHEMISTRY 19.8(2001):788-793. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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