Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish
文献类型：期刊论文
| 作者 | Xu, Tao1; Wang, Qiangwei2,3; Shi, Qipeng2; Fang, Qi2; Guo, Yongyong2; Zhou, Bingsheng2 |
| 刊名 | ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
 |
| 出版日期 | 2015-09-01 |
| 卷号 | 40期号:2页码:581-586 |
| 关键词 | TDCPP Bioconcentration and metabolism Zebrafish Thyroid hormones |
| ISSN号 | 1382-6689 |
| 英文摘要 | Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) is an organophosphate widely used as a flame retardant, and has frequently been detected in the environment and biota. The present study investigates the bioconcentration and metabolism of TDCPP in fish. Zebrafish embryos (from 2 h post-fertilization) were exposed to TDCPP (0, 4, 20 and 100 mu g/L) for six months. Exposure to TDCPP significantly induced phase I metabolic enzymes 7-ethoxyresorufin O-deethylase (EROD) and 7-methoxyresorufin 0-demethylase (MROD) in fish. The mRNA expression of genes related to Phase I and II metabolic enzymes, such as cyp1a1, cyp1b1, cyp1c1 and ugt1ab were also significantly upregulated. Exposure to TDCPP significantly reduced plasma thyroxine (T-4) and 3,5,3'-triiodothyronine (T-3) levels in females. Chemicals analysis indicated significant levels of TDCPP and its metabolite, bis (1,3-dichloro-2-propyl) phosphate (BDCPP), in the liver. The present study reveals that exposure to low concentrations of TDCPP can cause bioconcentration in fish, and TDCPP can be readily metabolized in liver. (C) 2015 Elsevier B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Environmental Sciences ; Pharmacology & Pharmacy ; Toxicology |
| 研究领域[WOS] | Environmental Sciences & Ecology ; Pharmacology & Pharmacy ; Toxicology |
| 关键词[WOS] | ORGANOPHOSPHATE FLAME RETARDANTS ; MESSENGER-RNA EXPRESSION ; DEETHYLASE EROD ACTIVITY ; ENDOCRINE DISRUPTION ; IN-VITRO ; MASS-SPECTROMETRY ; CHICKEN EMBRYOS ; CELL-LINE ; HYDROCARBON ; RECEPTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000362619100033 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.ihb.ac.cn/handle/342005/27274]  |
| 专题 | 水生生物研究所_水环境工程研究中心_期刊论文 |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Puwai Hosp, Wuhan 430033, Peoples R China 2.Chinese Acad Sci, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China 3.Zhejiang Univ, Inst Pesticide & Environm Toxicol, Hangzhou 310058, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Tao,Wang, Qiangwei,Shi, Qipeng,et al. Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish[J]. ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,2015,40(2):581-586. |
| APA | Xu, Tao,Wang, Qiangwei,Shi, Qipeng,Fang, Qi,Guo, Yongyong,&Zhou, Bingsheng.(2015).Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish.ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY,40(2),581-586. |
| MLA | Xu, Tao,et al."Bioconcentration, metabolism and alterations of thyroid hormones of Tris(1,3-dichloro-2-propyl) phosphate (TDCPP) in Zebrafish".ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY 40.2(2015):581-586. |
入库方式： OAI收割
来源：水生生物研究所
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