An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent
文献类型：期刊论文
| 作者 | Feng, JH; Li, XJ; Pei, FK; Sun, GY; Zhang, X; Liu, ML |
| 刊名 | MAGNETIC RESONANCE IMAGING
 |
| 出版日期 | 2002-06-01 |
| 卷号 | 20期号:5页码:407-412 |
| 关键词 | gadolinium polyoxometalates relaxivity MRI contrast agent |
| 英文摘要 | Two gadolinium polyoxometalates, K9GdW10O36 and K-11 [Gd(PW11O39)(2)], have been evaluated both in vivo and in vitro as candidates for tissue-specific MRI contrast agents. T-1-relaxivities of 6.89 mM(-1) . s(-1) for K9GdW10O36 and 5.27 mM(-1) . s(-1) for K-11[Gd(PW11O39)(2)] are slightly higher than that of the commercial MRI contrast agent (Gd-DTPA). Both compounds bind with bovine serum albumin and human serum transferrin and favorable liver-specific contrast enhancement in in vivo MRI with Sprague-Dawley rats after i.v. administration has been demonstrated. Imaging studies demonstrate that the two agents have a long residence time, showing MR signal enhancement in the liver for more than 40 min, longer than commercially available contrast agents. In vivo and in vitro assays showed that GdW10 and Gd(PW11)(2) are promising liver-specific MRI contrast agents and GdW10 may be used in the diagnosis of the pathological state. However, with the higher acute toxicity, the two gadolinium polyoxometalates need to be modified and studied further before clinical use. (C) 2002 Elsevier Science Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | RELAXATION ; COMPLEXES ; WATER ; NANOPARTICLES ; STABILITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000177930300006 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8676]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, JH,Li, XJ,Pei, FK,et al. An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent[J]. MAGNETIC RESONANCE IMAGING,2002,20(5):407-412. |
| APA | Feng, JH,Li, XJ,Pei, FK,Sun, GY,Zhang, X,&Liu, ML.(2002).An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent.MAGNETIC RESONANCE IMAGING,20(5),407-412. |
| MLA | Feng, JH,et al."An evaluation of gadolinium polyoxornetalates as possible MRI contrast agent".MAGNETIC RESONANCE IMAGING 20.5(2002):407-412. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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