Hepatic targeting of macromolecular MRI contrast agents
文献类型：期刊论文
| 作者 | Yan, GP; Zhuo, RX; Xu, MY; Zhang, X; Li, LY |
| 刊名 | POLYMER INTERNATIONAL
 |
| 出版日期 | 2002-10-01 |
| 卷号 | 51期号:10页码:892-898 |
| 关键词 | magnetic resonance imaging (MRI) contrast agent gadolinium complex polyester relaxivity liver-targeting |
| 英文摘要 | Water-soluble polyester ligands were synthesized by the polycondensation of diethylenetriaminepentaacetic dianhydride (DTPAA) with protected polyalcohol 3-O-benzyl-glycerol (3-O-Bz-GLYC), pentaerythritol monobenzaldehyde (S-Bz-PETO) and N-benzyldiethanolamine (N-Bz-DEA), respectively, and the protecting groups were then removed by hydrogenation to give polyesters P(DTPA-GLYC), P(DTPA-PETO) and P(DTPA-DEA). In the same manner, by adding ethylene glycol (EG) monomer into the polymerization system, polyesters P(DTPA-GLYC-EG), P(DTPA-PETO-EG) and P(DTPA-DEA-EG) were also synthesized. Pyridoxamine was chosen as a liver-targeting group and it was first chlorocarbonylated and then incorporated into polyesters. The polyester ligands containing pyridoxamine group thus prepared were further reacted with GdCl3 in water at room temperature to give the corresponding hepatic-targeting polyester gadolinium complexes. These macromolecular ligands and their gadolinium complexes were characterized by H-1 NMR, IR, UV and elementary analysis. Relaxivity studies showed that these polyester gadolinium complexes possess higher relaxation effectiveness than that of the clinically used small molecular gadolinium complex Gd-DTPA. In vitro cytotoxicity assay demonstrated that these macromolecular ligands and their gadolinium complexes have low cytotoxicity to the human normal liver cells (L-02). Magnetic resonance imaging of the liver in rats indicated that these polyester MRI contrast agents containing pyridoxamine group exhibit liver-targeting property. (C) 2002 Society of Chemical Industry. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Polymer Science |
| 研究领域[WOS] | Polymer Science |
| 收录类别 | SCI ; ISTP |
| 语种 | 英语 |
| WOS记录号 | WOS:000179103200011 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8692]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, GP,Zhuo, RX,Xu, MY,et al. Hepatic targeting of macromolecular MRI contrast agents[J]. POLYMER INTERNATIONAL,2002,51(10):892-898. |
| APA | Yan, GP,Zhuo, RX,Xu, MY,Zhang, X,&Li, LY.(2002).Hepatic targeting of macromolecular MRI contrast agents.POLYMER INTERNATIONAL,51(10),892-898. |
| MLA | Yan, GP,et al."Hepatic targeting of macromolecular MRI contrast agents".POLYMER INTERNATIONAL 51.10(2002):892-898. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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