Tumor-selective macromolecular MRI contrast agents
文献类型：期刊论文
| 作者 | Yan, GP; Zhuo, RX; Yang, YH; Li, LY; Liu, ML; Ye, CH |
| 刊名 | JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
 |
| 出版日期 | 2002-03-01 |
| 卷号 | 17期号:2页码:139-151 |
| 英文摘要 | Tumor-selective macromolecular ligands containing 5-(p-Carbonyloxyphenyl)-10,15,20-triphenylporphyrin (HPTP) moiety (PHEA-DTPA-HPTP and PAEA-DTPA-HPTP) were prepared by the incorporation of diethylenetriaminepentaacetic acid (DTPA) and 5-(p-hydroxylphenyl)-10,15, 20-triphenylporphyrin (HPTP) as the tumor-selective group in poly [alpha,beta-(N(2-hydroxyethyl)-L-aspartamide)] (PHEA) and poly-[alpha,beta-(N-(2-aminoethyl)-L-aspartamide)] (PAEA). These ligands were further complexed with gadolinium chloride to form two tumor-selective macromolecular MRI contrast agents PHEA-Gd-DTPA-HPTP and PAEA-Gd-DTPA-HPTP. Relaxivity studies showed that both the polyaspartamide-gadolinium complexes possess higher relaxation effectiveness than that of the clinically used Gd-DTPA. Magnetic resonance imaging of tumors in mice indicated that these two polyaspartamide MRI contrast agents containing 5-(p-Carbonlyoxyphenyl)-10,15,20-triphenylporphyrin moiety can significantly enhance the contrast MRIs of Hepatoma (H-22) and Ehrlich ascites carcinoma after injection and are taken up selectively by these cancers in mice. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Technology ; Physical Sciences |
| 类目[WOS] | Biotechnology & Applied Microbiology ; Materials Science, Biomaterials ; Polymer Science |
| 研究领域[WOS] | Biotechnology & Applied Microbiology ; Materials Science ; Polymer Science |
| 关键词[WOS] | ANTIVIRAL AGENT ; POLYASPARTAMIDE ; DERIVATIVES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000176199900005 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8704]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Univ, Dept Chem, Minist Educ, Lab Biomed Polymer Mat, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, GP,Zhuo, RX,Yang, YH,et al. Tumor-selective macromolecular MRI contrast agents[J]. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,2002,17(2):139-151. |
| APA | Yan, GP,Zhuo, RX,Yang, YH,Li, LY,Liu, ML,&Ye, CH.(2002).Tumor-selective macromolecular MRI contrast agents.JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS,17(2),139-151. |
| MLA | Yan, GP,et al."Tumor-selective macromolecular MRI contrast agents".JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS 17.2(2002):139-151. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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