Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents
文献类型：期刊论文
| 作者 | Feng, JH; Sun, GY; Pei, FK; Liu, ML |
| 刊名 | JOURNAL OF INORGANIC BIOCHEMISTRY
 |
| 出版日期 | 2002-11-25 |
| 卷号 | 92期号:3-4页码:193-199 |
| 关键词 | lanthanide polyoxometalates relaxivity MRI contrast agent |
| 英文摘要 | Two gadolinium polyoxometalates, Gd2P2W18O62 and K-15[(GdO)(3)(PW9O34)(2)], have been evaluated by in vivo as well as in vitro experiments as the candidates of tissue-specific magnetic resonance imaging (MRI) contrast agents. T-1-relaxivities of 28.4 mM(-1)-s(-1) for Gd2P2W18O62 and 11.2 mM(-1)-s(-1) for K-15[(GdO)(3)(PW9O34)(2)] (400 MHz, 25 degreesC) were higher than that of the commercial MRI contrast agent (GdDTPA). Their relaxivities in bovine serum albumin and human serum transferrin were also reported. The favorable liver-specific contrast enhancement and renal excretion capability in in vivo MRI with Sprague-Dawley rats after i.v. administration of K-15[(GdO)(3)(PW9O34)(2)] was demonstrated. In vivo and in vitro assay showed that K-15[(GdO)(3)(PW9O34)(2)] is a promising liver-specific MRI contrast agent. However, Gd2P2W18O62 did not show the favorable quality in vivo as expected from its high relaxivity in vitro, which was attributed to low bioavailability, indicating that it is of limited value as tissue-specific MRI contrast agent. (C) 2002 Elsevier Science Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemistry & Molecular Biology ; Chemistry, Inorganic & Nuclear |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | HETEROPOLY COMPLEXES ; PROTON RELAXATION ; SERUM-ALBUMIN ; GLIOMA MODEL ; WATER ; STABILITY ; DEXTRAN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000179620600008 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8708]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng, JH,Sun, GY,Pei, FK,et al. Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents[J]. JOURNAL OF INORGANIC BIOCHEMISTRY,2002,92(3-4):193-199. |
| APA | Feng, JH,Sun, GY,Pei, FK,&Liu, ML.(2002).Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents.JOURNAL OF INORGANIC BIOCHEMISTRY,92(3-4),193-199. |
| MLA | Feng, JH,et al."Comparison between GdDTPA and two gadolinium polyoxometalates as potential MRI contrast agents".JOURNAL OF INORGANIC BIOCHEMISTRY 92.3-4(2002):193-199. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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