NMR study on the low-affinity interaction of human serum albumin with diclofenac sodium
文献类型：期刊论文
| 作者 | Ji, ZS; Li, CG; Mao, XA; Liu, ML; Hu, JM |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2002-08-01 |
| 卷号 | 50期号:8页码:1017-1021 |
| 关键词 | diclofenac sodium human serum albumin NMR spin-lattice relaxation rate Langmuir adsorption isotherm |
| 英文摘要 | The low-affinity interaction between human serum albumin (HSA) and Diclofenac sodium (DCF) was studied using NMR techniques. Both C-13-NMR chemical shift and linewidth show that the dichlorophenyl ring in DCF molecule plays a primary role in its interaction with HSA. Langmuir adsorption isotherm was applied to evaluate the association constant K and the number of binding sites n of the drug/HSA complex through H-1-NMR spin-lattice relaxation measurement. The results indicate that Langmuir isotherm can perfectly explain the capacity of low-affinity binding of proteins for the ligands. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Pharmacology & Pharmacy ; Chemistry |
| 关键词[WOS] | NUCLEAR-MAGNETIC-RESONANCE ; DRUG BINDING-SITES ; PROTEIN-BINDING ; PHARMACOKINETIC PROPERTIES ; RELAXATION ; DIFFUSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000177186100002 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8772]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Univ, Dept Anal Measurement Sci, Wuhan 430072, Peoples R China 2.Acad Sinica, Wuhan Inst Phys & Math, Lab Magnet Resoannce & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, ZS,Li, CG,Mao, XA,et al. NMR study on the low-affinity interaction of human serum albumin with diclofenac sodium[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2002,50(8):1017-1021. |
| APA | Ji, ZS,Li, CG,Mao, XA,Liu, ML,&Hu, JM.(2002).NMR study on the low-affinity interaction of human serum albumin with diclofenac sodium.CHEMICAL & PHARMACEUTICAL BULLETIN,50(8),1017-1021. |
| MLA | Ji, ZS,et al."NMR study on the low-affinity interaction of human serum albumin with diclofenac sodium".CHEMICAL & PHARMACEUTICAL BULLETIN 50.8(2002):1017-1021. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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