Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI
文献类型：期刊论文
| 作者 | Sun, GY; Feng, JH; Jing, FY; Pei, FK; Liu, ML |
| 刊名 | JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
 |
| 出版日期 | 2003-09-01 |
| 卷号 | 265期号:2页码:123-129 |
| 关键词 | magnetic resonance imaging contrast agent relaxivity polysaccharide |
| 英文摘要 | Macromolecular conjugates of two kinds of natural polysaccharides, that from Panax quinquefolium linn (PQPS) and Ganoderma applanatum pat (GAPS), with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) have been synthesized and characterized by means of FTIR, elementary analysis and ICP-AES. Their stability was investigated by competition study with Ca2+, EDTA (ethylenediaminetetraacetic acid) and DTPA. Polysaccharide-bound complexes exhibit T-1 relaxivities of 1.5-1.7 times that of Gd-DTPA in D2O at 25degreesC and 9.4T. MR imaging of Sprague-Dawley (SD) rats showed remarkable enhancement in rat liver and kidney after i.v. injection of these two complexes: liver parenchyma 60.9+/-5.6%, 57.8+/-7.4% at 65-85 min; kidney 144.9+/-14.5%, 199.9+/-25.4% at 10-30 min for PQPS-GdDTPA, GAPS-Gd-DTPA at gadolinium dose of 0.083 and 0.082 mmol/kg, respectively. Our preliminary in vivo and in vitro study indicates that the two kinds of polysaccharide-bound complexes are potential tissue-specific contrast agents for MRI. (C) 2003 Elsevier Science B.V. All rights reserved. |
| WOS标题词 | Science & Technology ; Technology ; Physical Sciences |
| 类目[WOS] | Materials Science, Multidisciplinary ; Physics, Condensed Matter |
| 研究领域[WOS] | Materials Science ; Physics |
| 关键词[WOS] | MAGNETIC-RESONANCE ; SERUM-ALBUMIN ; GADOLINIUM(III) ; RELAXATION ; DEXTRAN ; BIODISTRIBUTION ; DERIVATIVES ; MODEL ; ACID |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000185120100004 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8832]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Sun, GY,Feng, JH,Jing, FY,et al. Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI[J]. JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,2003,265(2):123-129. |
| APA | Sun, GY,Feng, JH,Jing, FY,Pei, FK,&Liu, ML.(2003).Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI.JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS,265(2),123-129. |
| MLA | Sun, GY,et al."Synthesis and evaluation of novel polysaccharide-Gd-DTPA compounds as contrast agent for MRI".JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS 265.2(2003):123-129. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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