Cisplatin forms a 1 : 2 complex with ATP in aqueous solutions between pH 2 and 9
文献类型：期刊论文
| 作者 | Jiang, L; Mao, XA |
| 刊名 | POLYHEDRON
 |
| 出版日期 | 2003-02-15 |
| 卷号 | 22期号:4页码:611-616 |
| 关键词 | ATP-cisplatin complexes pH variation NMR DOSY long range H-1-N-15 HMQC |
| 英文摘要 | Interaction of ATP with cisplatin in the pH range 1.9-9.5 was studied by NMR. A new complex with the composition Pt(NH3)(2)(ATP)(2), which formed very slowly after cisplatin was added to ATP solution, was identified by DOSY and long range H-1-N-15 HMQC experiments. In the complex, ATP bound Pt at N7, and the N7-Pt bond showed the nature of kinetically inert interaction. At low pH, beside the 2:1 complex of N7 type, a 1:1 complex of NI type co-existed in the solution but the binding interaction was ionic and the complex exchanged rapidly with free ATP on the NMR time scale. (C) 2002 Elsevier Science Ltd. All rights reserved. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Inorganic & Nuclear ; Crystallography |
| 研究领域[WOS] | Chemistry ; Crystallography |
| 关键词[WOS] | BINDING-SITE ; ANTICANCER DRUGS ; NMR EVIDENCE ; DNA ADDUCTS ; CONFORMATION ; SPECTROSCOPY ; NUCLEOTIDES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000181260600019 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8845]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, L,Mao, XA. Cisplatin forms a 1 : 2 complex with ATP in aqueous solutions between pH 2 and 9[J]. POLYHEDRON,2003,22(4):611-616. |
| APA | Jiang, L,&Mao, XA.(2003).Cisplatin forms a 1 : 2 complex with ATP in aqueous solutions between pH 2 and 9.POLYHEDRON,22(4),611-616. |
| MLA | Jiang, L,et al."Cisplatin forms a 1 : 2 complex with ATP in aqueous solutions between pH 2 and 9".POLYHEDRON 22.4(2003):611-616. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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