Changes in the proton T-2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T
文献类型：期刊论文
| 作者 | Lei, H; Zhang, Y; Zhu, XH; Chen, W |
| 刊名 | MAGNETIC RESONANCE IN MEDICINE
 |
| 出版日期 | 2003-06-01 |
| 卷号 | 49期号:6页码:979-984 |
| 关键词 | BOLD forebrain ischemia T-2 relaxation time rat magnetic resonance spectroscopy cerebral metabolite |
| 英文摘要 | Proton T-2 relaxation times of cerebral water and metabolites were measured before, during, and after transient forebrain ischemia in rat at 9.4 T using localized proton magnetic resonance spectroscopy (H-1-MRS) with Hahn echoes formed at different echo times (TEs). It was found that the T-2 values of water and N-acetyl aspartate (NAA) methyl, but not total creatine (tCr) methyl, decrease significantly (similar to10%) during ischemia, and this T-2 reduction is reversed by reperfusion. The T-2 reduction observed for NAA was most likely caused by the extravascular component of the blood oxygenation level-dependent (BOLD) effect induced by a drastically increased deoxyhemoglobin content during ischemia. The absence of T-2 changes for tCr can probably be explained by the fact that the BOLD-related T-2 decrease was counterbalanced by the conversion of phosphocreatine (PCr) to creatine (Cr), which has a longer T-2 than PCr, during ischemia. The changes in T-2 should be taken into account for the quantification of metabolite concentrations during ischemia. (C) 2003 Wiley-Liss, Inc. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 研究领域[WOS] | Radiology, Nuclear Medicine & Medical Imaging |
| 关键词[WOS] | HUMAN BRAIN ; IN-VIVO ; H-1-NMR SPECTROSCOPY ; N-ACETYLASPARTATE ; GLOBAL-ISCHEMIA ; FOCAL ISCHEMIA ; BLOOD-FLOW ; ECHO-TIME ; H-1 MRS ; DIFFUSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000183271200001 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8926]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ Minnesota, Sch Med, Ctr Magnet Resonance Res, Dept Radiol, Minneapolis, MN 55455 USA 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Mol & Atom Phys, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lei, H,Zhang, Y,Zhu, XH,et al. Changes in the proton T-2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T[J]. MAGNETIC RESONANCE IN MEDICINE,2003,49(6):979-984. |
| APA | Lei, H,Zhang, Y,Zhu, XH,&Chen, W.(2003).Changes in the proton T-2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T.MAGNETIC RESONANCE IN MEDICINE,49(6),979-984. |
| MLA | Lei, H,et al."Changes in the proton T-2 relaxation times of cerebral water and metabolites during forebrain ischemia in rat at 9.4 T".MAGNETIC RESONANCE IN MEDICINE 49.6(2003):979-984. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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