Progress in nuclear magnetic resonance study on the interaction between drug ligand and macromolecular receptor
文献类型：期刊论文
| 作者 | Ji, ZS; Liu, ML; Hu, JM |
| 刊名 | CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2004-11-01 |
| 卷号 | 32期号:11页码:1532-1537 |
| 关键词 | nuclear magnetic resonance drug screening review |
| 英文摘要 | The interaction between drug and target macromolecule in vivo is one of the most important factors that determine the therapeutic activity and metabolic stability of the drug. How to rapidly and efficiently discover drug that can interact with target molecular and inhibit its in vitro activity has become an issue of major concern in pharmaceutical industries. Nuclear magnetic resonance (NMR) is now a very important approach to study the interaction between small ligand and biomolecule. Both ligand and receptor experience changes in the interaction process. Drug screening by NMR can be achieved by monitoring signals from ligand. The recent developments in this field are reviewed. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Analytical |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | HUMAN SERUM-ALBUMIN ; DIFFUSION-EDITED NMR ; LOW-AFFINITY BINDING ; SCREENING MIXTURES ; CHEMICAL-EXCHANGE ; LEAD GENERATION ; FIELD GRADIENT ; ORDERED NMR ; SPECTROSCOPY ; DISCOVERY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000225615700029 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8970]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Wuhan Univ, Ctr Anal & Measurement, Wuhan 430072, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, ZS,Liu, ML,Hu, JM. Progress in nuclear magnetic resonance study on the interaction between drug ligand and macromolecular receptor[J]. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,2004,32(11):1532-1537. |
| APA | Ji, ZS,Liu, ML,&Hu, JM.(2004).Progress in nuclear magnetic resonance study on the interaction between drug ligand and macromolecular receptor.CHINESE JOURNAL OF ANALYTICAL CHEMISTRY,32(11),1532-1537. |
| MLA | Ji, ZS,et al."Progress in nuclear magnetic resonance study on the interaction between drug ligand and macromolecular receptor".CHINESE JOURNAL OF ANALYTICAL CHEMISTRY 32.11(2004):1532-1537. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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