Simplified methods for calculating cerebral metabolic rate of oxygen based on O-17 magnetic resonance spectroscopic imaging measurement during a short O-17(0) inhalation
文献类型：期刊论文
| 作者 | Zhang, NY; Zhu, XH; Lei, H; Ugurbil, K; Chen, W |
| 刊名 | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
 |
| 出版日期 | 2004-08-01 |
| 卷号 | 24期号:8页码:840-848 |
| 关键词 | O-17 NMR O-17 MR spectroscopic imaging cerebral blood flow cerebral metabolic rate of oxygen CMRO2 |
| 英文摘要 | It has recently been shown that O-17 magnetic resonance (MR) spectroscopic imaging at ultrahigh fields provides a reliable method for measuring CMRO2 during a short period of O-17(2) gas inhalation. The mathematical (or complete) model used in the O-17 MR method for calculating CMRO2 requires simultaneous measurements of multiple parameters including the concentration of H-2 O-17 produced in the brain tissue from inhaled O-17(2) gas (C-b), CBF, and the input Junction for the H-2 O-17(2) concentration in the feeding artery (C-a). Both invasive and noninvasive measurements are involved in determining all of these parameters. In this article, two simplified methods are proposed and validated for calculating CMRO2 based on O-17 MR measurement(s); the first method requires the measurements of C-b and CBF, but not C-a, and the second method only requires a single noninvasive measurement of C-b. The simplified methods were used to calculate CMRO2 in anesthetized rat brain, and the results were compared with those obtained using the complete model. The results from this work show (1) the validity of the simplified methods for quantifying CMRO2, and (2) the feasibility for establishing a completely noninvasive O-17 MR approach for imaging CMRO2 in vivo. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Endocrinology & Metabolism ; Hematology ; Neurosciences |
| 研究领域[WOS] | Endocrinology & Metabolism ; Hematology ; Neurosciences & Neurology |
| 关键词[WOS] | INVIVO NMR-SPECTROSCOPY ; BLOOD-FLOW ; PARTITION-COEFFICIENT ; CONSUMPTION ; WATER ; BRAIN ; PERFUSION ; HEMOGLOBIN ; FIELD ; MRI |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000223133600002 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/8991]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Univ Minnesota, Sch Med, Ctr Magnet Resonance Res, Dept Radiol, Minneapolis, MN 55455 USA 2.Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Mol Atom Phys, Wuhan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, NY,Zhu, XH,Lei, H,et al. Simplified methods for calculating cerebral metabolic rate of oxygen based on O-17 magnetic resonance spectroscopic imaging measurement during a short O-17(0) inhalation[J]. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,2004,24(8):840-848. |
| APA | Zhang, NY,Zhu, XH,Lei, H,Ugurbil, K,&Chen, W.(2004).Simplified methods for calculating cerebral metabolic rate of oxygen based on O-17 magnetic resonance spectroscopic imaging measurement during a short O-17(0) inhalation.JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM,24(8),840-848. |
| MLA | Zhang, NY,et al."Simplified methods for calculating cerebral metabolic rate of oxygen based on O-17 magnetic resonance spectroscopic imaging measurement during a short O-17(0) inhalation".JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM 24.8(2004):840-848. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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