Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes
文献类型：期刊论文
| 作者 | Yu, KC; Wan, FX; Zhang, Y; Zhou, JL; Lu, G; Liu, ML; Ding, SW |
| 刊名 | CHINESE JOURNAL OF INORGANIC CHEMISTRY
 |
| 出版日期 | 2004-04-01 |
| 卷号 | 20期号:4页码:389-393 |
| 关键词 | ester-amid gadolinium complex liver-selecting contrast agent relaxivity T-1-weighted imaging |
| 英文摘要 | Four new ester-amido ligands were synthesized by esterification of mono-iso-butyl diethylenetriaminepentaacetate and mono-iso-butyl ethylenediaminetetraacetate with N,N'-ethylene bis-lactamide and NN'-1,6-hexamethylenebislactamide, respectively. The corresponding Gd(III) complexes were made by reacting the ligands with Gd2O3. All ligands and complexes were characterized: by FT-IR, H-1 NMR and elemental analysis. The measured longitudinal relaxivity of these complexes were all higher than that of Gd-DTPA. The investigation on cute toxicity and T-1-weighted imaging of complex derived from mono-N,N'-ethylenebislactamide ester diethlenetriaminepentaacetate were performed. No cute toxicity was found. The tested complex exhibited the higher enhancement on MRI signal intensity in rat liver, comparing with Gd-DTPA. |
| WOS标题词 | Science & Technology ; Physical Sciences |
| 类目[WOS] | Chemistry, Inorganic & Nuclear |
| 研究领域[WOS] | Chemistry |
| 关键词[WOS] | AGENTS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000220795100004 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9004]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Dept Chem, Wuhan 430074, Peoples R China 2.Chinese Acad Sci, Wuhan Inst Phys & Math, Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China 3.Natl Sun Yat Sen Univ, Dept Chem, Kaohsiung 80424, Taiwan 4.Natl Sun Yat Sen Univ, Ctr Nanosci & Nanotechnol, Kaohsiung 80424, Taiwan |
| 推荐引用方式 GB/T 7714 | Yu, KC,Wan, FX,Zhang, Y,et al. Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes[J]. CHINESE JOURNAL OF INORGANIC CHEMISTRY,2004,20(4):389-393. |
| APA | Yu, KC.,Wan, FX.,Zhang, Y.,Zhou, JL.,Lu, G.,...&Ding, SW.(2004).Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes.CHINESE JOURNAL OF INORGANIC CHEMISTRY,20(4),389-393. |
| MLA | Yu, KC,et al."Synthesis and MRI relaxation enhancement of mono-exter-amido gadolinium complexes".CHINESE JOURNAL OF INORGANIC CHEMISTRY 20.4(2004):389-393. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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