H-1 NMR spectroscopic evidence of interaction between ibuprofen and lipoproteins in human blood plasma
文献类型：期刊论文
| 作者 | Yang, YH; Bai, GY; Zhang, X; Ye, CH; Liu, ML |
| 刊名 | ANALYTICAL BIOCHEMISTRY
 |
| 出版日期 | 2004-01-15 |
| 卷号 | 324期号:2页码:292-297 |
| 关键词 | nuclear magnetic resonance ibuprofen lipoproteins unsaturated lipids phosphatidylcholine sphingomyelin |
| 英文摘要 | Recent studies have suggested that ibuprofen inhibits low-density lipoprotein oxidation in a high dose-dependent manner and is a promising drug for treatment of the conditions associated with atherosclerosis. In this article, we present the NMR spectroscopic evidence for the interaction between ibuprofen and phospholipids in lipoprotein particles in intact human plasma. Ibuprofen caused chemical shift upfield drifts for the protons of -N+(CH3)3 moieties of phosphatidylcholine and sphingomyelin, olefinic chains (-CHdouble bondCH-, -CHdouble bondCHCH(2)CHdouble bondCH-, -(CH2)(n)CH(2)CHdouble bond), and (CH2)(n) and CH3 groups, from unsaturated lipids in lipoprotein particles. The ibuprofen may interact directly with the above-mentioned groups of phospholipids or induce structural changes in the lipoproteins. This may shed light on the mechanism by which the drug protects against oxidative modification of lipoproteins. (C) 2003 Elsevier Inc. All rights reserved. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine ; Physical Sciences |
| 类目[WOS] | Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical |
| 研究领域[WOS] | Biochemistry & Molecular Biology ; Chemistry |
| 关键词[WOS] | NUCLEAR-MAGNETIC-RESONANCE ; LOW-DENSITY-LIPOPROTEIN ; LIGAND-RECEPTOR INTERACTIONS ; DIFFUSION-EDITED NMR ; MOLECULAR-DIFFUSION ; AFFINITY NMR ; SPIN-ECHO ; MIXTURES ; H-1 ; PHOSPHATIDYLCHOLINE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000187734000016 |
| 公开日期 | 2015-12-08 |
| 源URL | [http://ir.wipm.ac.cn/handle/112942/9011]  |
| 专题 | 武汉物理与数学研究所_2011年以前论文发表（包括2011年） |
| 作者单位 | Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yang, YH,Bai, GY,Zhang, X,et al. H-1 NMR spectroscopic evidence of interaction between ibuprofen and lipoproteins in human blood plasma[J]. ANALYTICAL BIOCHEMISTRY,2004,324(2):292-297. |
| APA | Yang, YH,Bai, GY,Zhang, X,Ye, CH,&Liu, ML.(2004).H-1 NMR spectroscopic evidence of interaction between ibuprofen and lipoproteins in human blood plasma.ANALYTICAL BIOCHEMISTRY,324(2),292-297. |
| MLA | Yang, YH,et al."H-1 NMR spectroscopic evidence of interaction between ibuprofen and lipoproteins in human blood plasma".ANALYTICAL BIOCHEMISTRY 324.2(2004):292-297. |
入库方式： OAI收割
来源：武汉物理与数学研究所
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