Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal
文献类型：期刊论文
| 作者 | Zhao, Yuming1,2,3; Xu, Pingxiang1; Hu, Shengquan4; Du, Libo5; Xu, Zhiqing2,3; Zhang, Huan4; Cui, Wei4; Mak, Shinghung4; Xu, Daping4; Shen, Jianggang6 |
| 刊名 | EUROPEAN JOURNAL OF PHARMACOLOGY
 |
| 出版日期 | 2015-10-15 |
| 卷号 | 765页码:437-446 |
| 关键词 | Tanshinone II A Neurodegeneration Neuronal differentiation Caveolin-1 BDNF NGF |
| 英文摘要 | Neuron loss is one fundamental features of neurodegenerative diseases. Stimulating endogenous neurogenesis, especially neuronal differentiation, might potentially provide therapeutic effects to these diseases. In this study, tanshinone II A (TIIA), a multiple target neuroprotectant, was demonstrated to promote dose-dependent neuronal differentiation in three cell models of immortalized C17.2 neuronal stem cells, rat embryonic cortical neural stem cells (NSCs) and rat PC12 pheochromocytoma cells. In particular, TIIA exerted promising effects on NSCs even at the dose of 3 nM. In PC12 cells, TIIA activated mitogen-activated protein kinase 42/44 (MAPK42/44) and its downstream transcription factor, cAMP response element-binding protein (CREB). In addition, TIIA up-regulated the expressions of brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF). The MEK inhibitor and the antagonist to the receptors of NGF and BDNF could partially attenuate the differentiation effects, indicating that MAPK42/44 mediated BDNF and NGF signals were involved in TIIA's differentiation effects. Caveolin-1 (CAV-1), the major functional protein of membrane caveolae, plays critical roles in the endocytosis of exogenous materials. CAV1, which was activated by TIIA, might help TIIA transport across cell membrane to initiate its differentiation effects. It was proven by the evidences that suppressing the function of caveolin inhibited the differentiation effects of TIIA. Therefore, we concluded that TIIA promoted neuronal differentiation partially through MAPK42/44 mediated BDNF and NGF signals in a caveolae-dependent manner. (C) 2015 Elsevier B.V. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-22 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29187]  |
| 专题 | 化学研究所_分子动态与稳态结构实验室 |
| 作者单位 | 1.Capital Med Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100069, Peoples R China 2.Capital Med Univ, Beijing Inst Brain Disorders, Beijing 100069, Peoples R China 3.Capital Med Univ, Res Ctr Brain Disorders, Beijing 100069, Peoples R China 4.Hong Kong Polytech Univ, Inst Modern Med, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China 5.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 6.Univ Hong Kong, Sch Chinese Med, Pokfulam, Hong Kong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhao, Yuming,Xu, Pingxiang,Hu, Shengquan,et al. Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2015,765:437-446. |
| APA | Zhao, Yuming.,Xu, Pingxiang.,Hu, Shengquan.,Du, Libo.,Xu, Zhiqing.,...&Xue, Ming.(2015).Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal.EUROPEAN JOURNAL OF PHARMACOLOGY,765,437-446. |
| MLA | Zhao, Yuming,et al."Tanshinone II A, a multiple target neuroprotectant, promotes caveolae-dependent neuronal".EUROPEAN JOURNAL OF PHARMACOLOGY 765(2015):437-446. |
入库方式： OAI收割
来源：化学研究所
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