EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery
文献类型：期刊论文
| 作者 | Guan, Xingang1,2; Hu, Xiuli1; Cui, Fengchao3; Li, Yunqi3; Jing, Xiabing1; Xie, Zhigang1 |
| 刊名 | MACROMOLECULAR BIOSCIENCE
 |
| 出版日期 | 2015-11-01 |
| 卷号 | 15期号:11页码:1484-1489 |
| 关键词 | protein nanoparticle siRNA delivery tat |
| 英文摘要 | Development of an innovative nucleic acid nanocarriers still represents a challenge. In this study, we develop a protein nanoparticle (H6-TatEGFP) and examine its siRNA condensing activity. Gel retardation assay show that protein nanoparticle can condense siRNA into stable nanoparticle/siRNA complexes. UsingCy3-labelled siRNA, we also evaluate siRNA transport characteristic of protein nanoparticles in tumor cells, the results indicate that H6-TatEGFP nanoparticle may be a potential nanocarrier for siRNA in tumor cells. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-22 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29170]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China 2.Beihua Univ, Life Sci Res Ctr, Jilin 132013, Peoples R China 3.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Synthet Rubber, Changchun 130022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guan, Xingang,Hu, Xiuli,Cui, Fengchao,et al. EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery[J]. MACROMOLECULAR BIOSCIENCE,2015,15(11):1484-1489. |
| APA | Guan, Xingang,Hu, Xiuli,Cui, Fengchao,Li, Yunqi,Jing, Xiabing,&Xie, Zhigang.(2015).EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery.MACROMOLECULAR BIOSCIENCE,15(11),1484-1489. |
| MLA | Guan, Xingang,et al."EGFP-Based Protein Nanoparticles with Cell-Penetrating Peptide for Efficient siRNA Delivery".MACROMOLECULAR BIOSCIENCE 15.11(2015):1484-1489. |
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来源：化学研究所
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