Functionalization of Block Copolypeptides via Thiol-yne Addition and Their Self-assembly Behavior in Solutions
文献类型：期刊论文
| 作者 | Chen, Ping1; Fu, Wen-xin2 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2015-10-20 |
| 期号 | 10页码:1223-1230 |
| 关键词 | Polypeptide Ring-opening polymerization Click chemistry Self-assembly |
| 英文摘要 | A series of polypeptide-based amphiphilic hybrid copolymers were synthesized via the combination of ring-opening polymerization (ROP) and thiol-yne click reaction. First, poly (ethylene glycol) -block-poly(gamma-propargyl-L-glutamate) (PEG-b-PPLG) diblock copolymers were prepared by ROP using a monoamine terminated poly(ethylene glycol) (PEG-NH2) as the initiator. Subsequently, the PPLG block was modified with a saturated hydrocarbon (1-octanethiol) or a superhydrophobic fluorinated side group (1-mercapto-1H, 1H, 211, 2H-perfluorooctane) by thiol-yne reaction with high efficiency. The self-assembly behavior of all obtained copolymers in solutions was finely investigated and characterized using Fourier transform infrared (FTIR) spectroscopy, circular dichroism (CD) spectroscopy, dynamic light scattering (DLS) and transmission electron microscopy (TEM). The polypeptide blocks were shown to exhibit a-helix conformations, and all copolymers could spontaneously self-assemble into sphere or rodlike micelles in aqueous or organic solution due to the different solubility of the distinct blocks. Such strategy offers a general and efficient way to achieve various amphiphlic hybrid copolymers using simple copolymer precursors, especially for the preparation of functional self-assembly materials with various architectures. Moreover, the self-assemblies of these functional amphiphilic copolypeptides could be easily modulated by tuning the optional macroinitiators and a series of functional thiols. |
| 收录类别 | SCI |
| 语种 | 英语 |
| 公开日期 | 2015-12-22 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/29199]  |
| 专题 | 化学研究所_高分子物理与化学实验室 |
| 作者单位 | 1.Huaiyin Normal Univ, Sch Chem & Chem Engn, Jiangsu Key Lab Chem Low Dimens Mat, Huaian 223300, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Ping,Fu, Wen-xin. Functionalization of Block Copolypeptides via Thiol-yne Addition and Their Self-assembly Behavior in Solutions[J]. ACTA POLYMERICA SINICA,2015(10):1223-1230. |
| APA | Chen, Ping,&Fu, Wen-xin.(2015).Functionalization of Block Copolypeptides via Thiol-yne Addition and Their Self-assembly Behavior in Solutions.ACTA POLYMERICA SINICA(10),1223-1230. |
| MLA | Chen, Ping,et al."Functionalization of Block Copolypeptides via Thiol-yne Addition and Their Self-assembly Behavior in Solutions".ACTA POLYMERICA SINICA .10(2015):1223-1230. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。