Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects
文献类型：期刊论文
| 作者 | Wang, Shuaiyu; Wang, Li-Jun; Jiang, Bo; Wu, Ning; Li, Xiangqian; Liu, Shaofang; Luo, Jiao; Shi, Dayong |
| 刊名 | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 16期号:6页码:13548-13560 |
| 英文摘要 | Bis-(2,3-dibromo-4,5-dihydroxy-phenyl)-methane (BDDPM) is a bromophenol first isolated from Rhodomelaceae confervoides. Our previous studies showed that BDDPM exerts PTP1B-inhibiting activity and anti-cancer activity against a wide range of tumor cells while it also showed lower cytotoxicity against normal cells. In the present study, we found that BDDPM exhibits significant activities toward angiogenesis in vitro. BDDPM inhibits multiple angiogenesis processes, including endothelial cell sprouting, migration, proliferation, and tube formation. Further kinase assays investigations found that BDDPM is a potent selective, but multi-target, receptor tyrosine kinase (RTKs) inhibitor. BDDPM (10 mu M) inhibits the activities of fibroblast growth factor receptor 2 and 3 (FGFR2, 3), vascular endothelial growth factor receptor 2 (VEGFR2) and platelet-derived growth factor receptor alpha (PDGFR alpha) (inhibition rate: 57.7%, 78.6%, 78.5% and 71.1%, respectively). Moreover, BDDPM also decreases the phosphorylation of protein kinase B (PKB/Akt) and endothelial nitric oxide synthase (eNOS), as well as nitric oxide (NO) production in a dose dependent manner. These results indicate that BDDPM can be exploited as an anti-angiogenic drug, or as a lead compound for the development of novel multi-target RTKs inhibitors. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000357492800092 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/48989]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | Chinese Acad Sci, Inst Oceanol, Qingdao 266071, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Shuaiyu,Wang, Li-Jun,Jiang, Bo,et al. Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2015,16(6):13548-13560. |
| APA | Wang, Shuaiyu.,Wang, Li-Jun.,Jiang, Bo.,Wu, Ning.,Li, Xiangqian.,...&Shi, Dayong.(2015).Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,16(6),13548-13560. |
| MLA | Wang, Shuaiyu,et al."Anti-Angiogenic Properties of BDDPM, a Bromophenol from Marine Red Alga Rhodomela confervoides, with Multi Receptor Tyrosine Kinase Inhibition Effects".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16.6(2015):13548-13560. |
入库方式： OAI收割
来源：海洋研究所
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