A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model
文献类型：期刊论文
| 作者 | Xia, Qing1,2 ; Wang, Baojie1; Liu, Mei1; Jiang, Keyong1; Wang, Lei1
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| 刊名 | FISH & SHELLFISH IMMUNOLOGY
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 46期号:2页码:686-692 |
| 关键词 | Vibrio Experimental challenges Cox proportional hazards (PH) model Mortality Prognostic index Litopenaeus vannamei |
| 英文摘要 | In the shrimp challenge test the Vibrio dosage, infection route, and strain are considered as risk factors that result in mortality. Assessment of Vibrio/shrimp interactions, and disease dynamics following infection by Vibrio, are useful techniques needed for detailed studies on the control of risk factors. In this paper we used an application of the Cox proportional hazard model to assess relative survival probability, estimate mortality risk, and construct a prognostic model to assess predictions of estimated time to death. Results indicate that infection route was the most important prognostic factor contributing to mortality in the challenge test (beta = 3.698, P < 0.000). The shrimp infection rate following injection was found to be 40.4 times greater than that following immersion (hazard ratio (HR) = 40.4; p = 0.000). Our results also indicated that the HR resulting in shrimp mortality following a high dose of 10(8) cfu/shrimp was significantly greater (HR = 5.9, P < 0.000), than that following a baseline dosage of 10(7) cfu/shrimp. Strain Vh was found to be more virulent than Strain Vp (HR = 4.8; P < 0.000). The prognostic index also indicated that the infection route is the most important prognostic factor contributing to mortality in the challenge test. (C) 2015 Elsevier Ltd. All rights reserved. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000363071200058 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/73941]  |
| 专题 | 海洋研究所_海洋生物技术研发中心 |
| 作者单位 | 1.Chinese Acad Sci, Inst Oceanol, Natl & Local Joint Engn Lab Ecol Mariculture, Qingdao, Shandong, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Qing,Wang, Baojie,Liu, Mei,et al. A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model[J]. FISH & SHELLFISH IMMUNOLOGY,2015,46(2):686-692. |
| APA | Xia, Qing,Wang, Baojie,Liu, Mei,Jiang, Keyong,&Wang, Lei.(2015).A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model.FISH & SHELLFISH IMMUNOLOGY,46(2),686-692. |
| MLA | Xia, Qing,et al."A new method to evaluate the effects of bacterial dosage, infection route and Vibrio strain in experimental challenges of Litopenaeus vannamei, based on the Cox proportional hazard model".FISH & SHELLFISH IMMUNOLOGY 46.2(2015):686-692. |
入库方式： OAI收割
来源：海洋研究所
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