Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection
文献类型：期刊论文
| 作者 | Kumari, Jaya1,2; Zhang, Zuobing1,3; Swain, Trilochan1; Chi, Heng1,4; Niu, Cuijuan3; Bogwald, Jarl1; Dalmo, Roy Ambli1 |
| 刊名 | FRONTIERS IN IMMUNOLOGY
 |
| 出版日期 | 2015-07-06 |
| 卷号 | 6期号:2015页码:1-11 |
| 关键词 | Atlantic salmon T-bet A. salmonicida gene expression mucosal immunity |
| 英文摘要 | The T-box transcription factor T-bet is expressed in a number of hematopoietic cell types in mammals and plays an essential role in the lineage determination of Th1 T-helper cells and is considered as an essential feature for both innate and adaptive immune responses in higher vertebrates. In the present study, we have identified and characterized the full-length Atlantic salmon T-bet cDNA (3502 bp). The putative primary structure of the polypeptide deduced from the cDNA sequence contained 612 aa, which possessed a T-box DNA binding domain. Phylogenetic study and gene synteny revealed it is as a homolog to mammalian T-bet. Quantitative PCR analysis of different tissues in healthy fish showed that salmon T-bet gene was highly expressed in spleen, followed by head kidney, and was expressed in intestine, skin, and liver at lower levels. Moreover, the time-dependent expression profile of T-bet, interferon gamma (IFN gamma), interleukin-22 (IL-22), and natural killer enhancement factor in mucosal tissues during water-borne infection with live Aeromonas salmonicida, indicated the involvement of T-bet in mucosal immune response in Atlantic salmon. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000358138500002 |
| 源URL | [http://ir.qdio.ac.cn/handle/337002/49053]  |
| 专题 | 海洋研究所_实验海洋生物学重点实验室 |
| 作者单位 | 1.Univ Tromso, Norwegian Coll Fishery Sci, Fac Biosci Fisheries & Econ, Tromso, Norway 2.NOFIMA, NO-9291 Tromso, Norway 3.Beijing Normal Univ, Coll Life Sci, Minist Educ, Key Lab Biodivers Sci & Ecol Engn, Beijing 100875, Peoples R China 4.Chinese Acad Sci, Inst Oceanol, Key Lab Expt Marine Biol, Qingdao, Peoples R China |
| 推荐引用方式 GB/T 7714 | Kumari, Jaya,Zhang, Zuobing,Swain, Trilochan,et al. Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection[J]. FRONTIERS IN IMMUNOLOGY,2015,6(2015):1-11. |
| APA | Kumari, Jaya.,Zhang, Zuobing.,Swain, Trilochan.,Chi, Heng.,Niu, Cuijuan.,...&Dalmo, Roy Ambli.(2015).Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection.FRONTIERS IN IMMUNOLOGY,6(2015),1-11. |
| MLA | Kumari, Jaya,et al."Transcription factor T-bet in Atlantic salmon: characterization and gene expression in mucosal tissues during Aeromonas salmonicida infection".FRONTIERS IN IMMUNOLOGY 6.2015(2015):1-11. |
入库方式： OAI收割
来源：海洋研究所
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