beta-Elemene reduces the progression of atherosclerosis in rabbits
文献类型：期刊论文
| 作者 | Zhong Ying1; Liu Jun1; Huo Wei-Min3; Duan Wen-Li1; Wang Xue1; Shang Jing1,2 |
| 刊名 | chinese journal of natural medicines
 |
| 出版日期 | 2015-06-01 |
| 卷号 | 13期号:6页码:415-420 |
| 关键词 | beta-Elemene Atherosclerosis Inflammation Macrophage TNF-alpha |
| 中文摘要 | the present study aimed at investigating the possible effects of beta-elemene on the progression of atherosclerosis in a rabbit model. the rabbit atherosclerosis model was established. by the combination of balloon angioplasty-induced endothelial injury and an atherogenic diet fed to the rabbits. new zealand white rabbits were randomly divided into four groups (8/group): the normal control group (fed with normal chow diet), and three experimental groups, placebo group, atorvastatin group, and beta-elemene group (received the atherogenic diet). after two weeks on the diet, the three experimental groups underwent balloon injury at right common carotid artery and were treated with drugs or placebo for five weeks. serum lipids were measured. carotid artery lesions were isolated for histological and immunohistochemical analysis. in vitro, raw264.7 macrophages were pretreated with beta-elemene and ox-ldl for 24 h and the viability of macrophages was assayed using the mtt method. tnf-alpha and il-6 were also determined. compared with the control group, the thickness of the atherosclerosis lesion in the placebo group was significantly increased; the thickness the drug treatment groups were significantly decreased, compared with that of the placebo group. the infiltration of macrophage was markedly reduced in the beta-elemene group compared with that of the placebo group. beta-elemene treatment also reduced the levels of tc, tg, and ldl-c, compared with the placebo group. beta-elemene decreased the tnf-alpha and il-6 levels in vitro. in conclusion, our results demonstrated that beta-elemene retarded the progression of atherosclerosis in vivo and in vitro, which may be related to the capacity of beta-elemene to reduce the infiltration of macrophages and suppress inflammatory factors. |
| 英文摘要 | the present study aimed at investigating the possible effects of beta-elemene on the progression of atherosclerosis in a rabbit model. the rabbit atherosclerosis model was established. by the combination of balloon angioplasty-induced endothelial injury and an atherogenic diet fed to the rabbits. new zealand white rabbits were randomly divided into four groups (8/group): the normal control group (fed with normal chow diet), and three experimental groups, placebo group, atorvastatin group, and beta-elemene group (received the atherogenic diet). after two weeks on the diet, the three experimental groups underwent balloon injury at right common carotid artery and were treated with drugs or placebo for five weeks. serum lipids were measured. carotid artery lesions were isolated for histological and immunohistochemical analysis. in vitro, raw264.7 macrophages were pretreated with beta-elemene and ox-ldl for 24 h and the viability of macrophages was assayed using the mtt method. tnf-alpha and il-6 were also determined. compared with the control group, the thickness of the atherosclerosis lesion in the placebo group was significantly increased; the thickness the drug treatment groups were significantly decreased, compared with that of the placebo group. the infiltration of macrophage was markedly reduced in the beta-elemene group compared with that of the placebo group. beta-elemene treatment also reduced the levels of tc, tg, and ldl-c, compared with the placebo group. beta-elemene decreased the tnf-alpha and il-6 levels in vitro. in conclusion, our results demonstrated that beta-elemene retarded the progression of atherosclerosis in vivo and in vitro, which may be related to the capacity of beta-elemene to reduce the infiltration of macrophages and suppress inflammatory factors. |
| WOS标题词 | science & technology ; life sciences & biomedicine |
| 类目[WOS] | integrative & complementary medicine ; pharmacology & pharmacy |
| 研究领域[WOS] | integrative & complementary medicine ; pharmacology & pharmacy |
| 关键词[WOS] | in-vitro ; cells ; inhibition ; expression ; carcinoma ; macrophages ; activation ; apoptosis ; alpha ; vegf |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000359754200003 |
| 源URL | [http://ir.nwipb.ac.cn/handle/363003/5543]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.China Pharmaceut Univ, State Key Lab Nat Med, New Drug Screening Ctr, Nanjing 210009, Jiangsu, Peoples R China 2.China Pharmaceut Univ, Jiangsu Key Lab TCM Evaluat & Translat Res, Nanjing 210009, Jiangsu, Peoples R China 3.Chinese Acad Sci, Northwest Inst Plateau Biol, Qinghai Key Lab Tibetan Med Pharmacol & Safety Ev, Xining 810008, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhong Ying,Liu Jun,Huo Wei-Min,et al. beta-Elemene reduces the progression of atherosclerosis in rabbits[J]. chinese journal of natural medicines,2015,13(6):415-420. |
| APA | Zhong Ying,Liu Jun,Huo Wei-Min,Duan Wen-Li,Wang Xue,&Shang Jing.(2015).beta-Elemene reduces the progression of atherosclerosis in rabbits.chinese journal of natural medicines,13(6),415-420. |
| MLA | Zhong Ying,et al."beta-Elemene reduces the progression of atherosclerosis in rabbits".chinese journal of natural medicines 13.6(2015):415-420. |
入库方式： OAI收割
来源：西北高原生物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。