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A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma
文献类型：期刊论文
| 作者 | Zhou, Wei; Ma, Yingyi; Yang, Huan2; Ding, Yi1; Luo, Xiangang2 |
| 刊名 | INTERNATIONAL JOURNAL OF NANOMEDICINE
 |
| 出版日期 | 2011 |
| 卷号 | 6页码:381-386 |
| 关键词 | localized surface plasmon resonance p53 protein biosensor oral squamous-cell carcinoma |
| 英文摘要 | By using triangular silver (Ag) nanoparticle array, a localized surface plasmon resonance (LSPR) nanosensor was fabricated and shown to sense serum p53 protein in vitro, which is involved in head and neck squamous cell carcinoma (HNSCC). The nanosensor consists of a triangular Ag nanoparticles array with single particle dimension of 120 nm in-plane width and 45 nm out-of-plane height. When examined using LSPR nanobiosensor, the results indicated significant difference in LSPR shifts (Delta lambda(max)) between HNSCC patient and control. Although there is need for precise quantification and large-scale prospective, this report shows that the LSPR nanobiosensor provides a promising platform with attractive advantages for serological diagnosis or molecular diagnosis in tumor, such as HNSCC. This is the first clinical application of the LSPR nanosensor in HNSCC. |
| WOS标题词 | Science & Technology ; Life Sciences & Biomedicine |
| 类目[WOS] | Nanoscience & Nanotechnology ; Pharmacology & Pharmacy |
| 研究领域[WOS] | Science & Technology - Other Topics ; Pharmacology & Pharmacy |
| 关键词[WOS] | PROTEIN ; ANTIGEN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000288248900040 |
| 公开日期 | 2015-12-24 |
| 源URL | [http://ir.ioe.ac.cn/handle/181551/3463]  |
| 专题 | 光电技术研究所_光电技术研究所被WoS收录文章 |
| 作者单位 | 1.Sichuan Univ, W China Coll Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China 2.Chinese Acad Sci, Inst Opt & Elect, State Key Lab Opt Technol Microfabricat, Chengdu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Wei,Ma, Yingyi,Yang, Huan,et al. A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2011,6:381-386. |
| APA | Zhou, Wei,Ma, Yingyi,Yang, Huan,Ding, Yi,&Luo, Xiangang.(2011).A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma.INTERNATIONAL JOURNAL OF NANOMEDICINE,6,381-386. |
| MLA | Zhou, Wei,et al."A label-free biosensor based on silver nanoparticles array for clinical detection of serum p53 in head and neck squamous cell carcinoma".INTERNATIONAL JOURNAL OF NANOMEDICINE 6(2011):381-386. |
入库方式： OAI收割
来源：光电技术研究所
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