Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry
文献类型：期刊论文
| 作者 | Levran, Orna1; Peles, Einat2,3; Randesi, Matthew1; da Rosa, Joel Correa4; Ott, Jurg5,6; Rotrosen, John7,8; Adelson, Miriam1,2,9; Kreek, Mary Jeanne1 |
| 刊名 | PHARMACOGENOMICS
 |
| 出版日期 | 2015 |
| 卷号 | 16期号:12页码:1329-1342 |
| 关键词 | ADRA1A adrenergic pathway African-American association study cocaine addiction genetic variants heroin addiction HTR3A HTR3B S100A10 serotonergic pathway SLC18A2 SLC6A4 stress |
| ISSN号 | 1462-2416 |
| 英文摘要 | Background: Drug addiction is influenced by genetic factors. Aim: To determine if genetic variants in the serotonergic and adrenergic pathways are associated with heroin and/or cocaine addiction. Subjects & methods: The study examined 140 polymorphisms in 19 genes in 1855 subjects with predominantly European or African ancestries. Results: A total of 38 polymorphisms (13 genes) showed nominal associations, including novel associations in S100A10 (p11) and SLC18A2 (VMAT2). The association of HTR3B SNP rs11606194 with heroin addiction in the European ancestry subgroup remained significant after correction for multiple testing (p(corrected) = 0.04). Conclusion: The study strengthens our previous findings of association of polymorphisms in HTR3A, HTR3B and ADRA1A. The study suggests partial overlap in genetic susceptibility between populations of different ancestry and between heroin and cocaine addiction. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000361142500001 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15209]  |
| 专题 | 心理研究所_健康与遗传心理学研究室 |
| 作者单位 | 1.Rockefeller Univ, Lab Biol Addict Dis, New York, NY 10065 USA 2.Tel Aviv Elias Sourasky Med Ctr, Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Tel Aviv, Israel 3.Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel 4.Rockefeller Univ, Ctr Clin & Translat Sci, New York, NY 10065 USA 5.Chinese Acad Sci, Inst Psychol, Beijing 100101, Peoples R China 6.Rockefeller Univ, Lab Stat Genet, New York, NY 10065 USA 7.VA New York Harbor Healthcare Syst, New York, NY 10010 USA 8.NYU, Sch Med, New York, NY 10010 USA 9.Dr Miriam & Sheldon G Adelson Clin Drug Abuse Tre, Las Vegas, NV 89169 USA |
| 推荐引用方式 GB/T 7714 | Levran, Orna,Peles, Einat,Randesi, Matthew,et al. Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry[J]. PHARMACOGENOMICS,2015,16(12):1329-1342. |
| APA | Levran, Orna.,Peles, Einat.,Randesi, Matthew.,da Rosa, Joel Correa.,Ott, Jurg.,...&Kreek, Mary Jeanne.(2015).Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry.PHARMACOGENOMICS,16(12),1329-1342. |
| MLA | Levran, Orna,et al."Susceptibility loci for heroin and cocaine addiction in the serotonergic and adrenergic pathways in populations of different ancestry".PHARMACOGENOMICS 16.12(2015):1329-1342. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。