Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII
文献类型：期刊论文
| 作者 | Wei, Yan1; Han, Chanshuai1; Wang, Yujing1,2; Wu, Beibei1,2; Su, Tao1; Liu, Ying1,3 ; He, Rongqiao1,4
|
| 刊名 | AGING CELL
 |
| 出版日期 | 2015-10-01 |
| 卷号 | 14期号:5页码:754-763 |
| 关键词 | hyperphosphorylation ribosylation Tau protein |
| ISSN号 | 1474-9718 |
| 英文摘要 | Type 2 diabetes mellitus (T2DM) is regarded as one of the serious risk factors for age-related cognitive impairment; however, a causal link between these two diseases has so far not been established. It was recently discovered that, apart from high D-glucose levels, T2DM patients also display abnormally high concentrations of uric D-ribose. Here, we show for the first time that the administration of D-ribose, the most active glycator among monosaccharides, produces high levels of advanced glycation end products (AGEs) and, importantly, triggers hyperphosphorylation of Tau in the brain of C57BL/6 mouse and neuroblastoma N2a cells. However, the administration of D-glucose showed no significant changes in Tau phosphorylation under the same experimental conditions. Crucially, suppression of AGE formation using an AGEs inhibitor (aminoguanidine) effectively prevents hyperphosphorylation of Tau protein. Further study shows AGEs resulted from ribosylation activate calcium-/calmodulin-dependent protein kinase type II (CaMKII), a key kinase responsible for Tau hyperphosphorylation. These data suggest that there is indeed a mechanistic link between ribosylation and Tau hyperphosphorylation. Targeting ribosylation by inhibiting AGE formation may be a promising therapeutic strategy to prevent Alzheimer's disease-like Tau hyperphosphorylation and diabetic encephalopathies. |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000360767200005 |
| 源URL | [http://ir.psych.ac.cn/handle/311026/15228]  |
| 专题 | 心理研究所_脑与认知科学国家重点实验室 |
| 作者单位 | 1.Chinese Acad Sci, Inst Biophys, State Key Lab Brain & Cognit Sci, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Capital Med Univ, Beijing Inst Brain Disorders, Alzheimers Dis Ctr, Beijing, Peoples R China 4.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wei, Yan,Han, Chanshuai,Wang, Yujing,et al. Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII[J]. AGING CELL,2015,14(5):754-763. |
| APA | Wei, Yan.,Han, Chanshuai.,Wang, Yujing.,Wu, Beibei.,Su, Tao.,...&He, Rongqiao.(2015).Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII.AGING CELL,14(5),754-763. |
| MLA | Wei, Yan,et al."Ribosylation triggering Alzheimer's disease-like Tau hyperphosphorylation via activation of CaMKII".AGING CELL 14.5(2015):754-763. |
入库方式： OAI收割
来源：心理研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。