中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
作者:
Zou, Zhi-feng
;
Yang, Lei
;
Nie, Hui-jun
;
Gao, Jing
;
Lei, Shu-min
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/22
proteolysis-targeting chimeras
tumor-targeted delivery
precise protein degradation
combination therapy
triple-negative breast cancer
Design, Synthesis, and Biological Evaluation of Novel Arylomycins against Multidrug-Resistant Gram-Negative Bacteria
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 25
作者:
Zhang, Yinyong
;
Zhang, Dan
;
Zhao, Wenhao
;
Li, Hongyuan
;
Lu, Zhengyu
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/22
Synaptotagmin 7 docks synaptic vesicles to support facilitation and Doc2α-triggered asynchronous release
期刊论文
OAI收割
ELIFE, 2024, 卷号: 12, 页码: 35
作者:
Wu, Zhenyong
;
Kusick, Grant F.
;
Berns, Manon M. M.
;
Raychaudhuri, Sumana
;
Itoh, Kie
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2024/05/07
asynchronous release
short-term plasticity
synaptotagmin
zap-and-freeze
iGluSnFR
synaptic vesicle docking
Mouse
Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1
期刊论文
OAI收割
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 14
作者:
Xie, Xiong
;
Lan, Qiaoshuai
;
Zhao, Jinyi
;
Zhang, Sulin
;
Liu, Lu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance
期刊论文
OAI收割
CANCER RESEARCH, 2024, 卷号: 84, 期号: 5, 页码: 688-702
作者:
Wang, Hui
;
Zhang, Yanyang
;
Tian, Yu
;
Yang, Wanlin
;
Wang, Yan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/05/07
Energy preservation for skeletal muscles: Shenqi Fuzheng injection prevents tissue wasting and restores bioenergetic profiles in a mouse model of chemotherapy-induced cachexia
期刊论文
OAI收割
PHYTOMEDICINE, 2024, 卷号: 125, 页码: 13
作者:
Li, Wei
;
Zhang, Zijia
;
Berik, Entezar
;
Liu, Yawen
;
Pei, Wenqiang
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/04/09
Shenqi Fuzheng injection
Chemotherapy-induce cachexia
Bioenergetic profiles
Glycolysis
TCA cycle
lipid metabolism
Quantitative proteomics reveals the protective effects of Yinchenzhufu decoction against cholestatic liver fibrosis in mice by inhibiting the PDGFRβ/PI3K/AKT pathway
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Meng, Qian
;
Zhu, Hongwen
;
Li, Yuanyuan
;
Peng, Xiaotian
;
Wang, Tianming
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Yinchenzhufu decoction
proteomics
cholestasis
liver fibrosis
PDGFR beta/PI3K/AKT
PROTAC Prodrug-Integrated Nanosensitizer for Potentiating Radiation Therapy of Cancer
期刊论文
OAI收割
ADVANCED MATERIALS, 2024, 页码: 12
作者:
Zhang, Shunan
;
Lai, Yi
;
Pan, Jiaxing
;
Saeed, Madiha
;
Li, Shiqin
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/04/09
active tumor targeting
nanosensitizer
PROTAC prodrug
radiation therapy
tumor microenvironment
Discovery of Pyrido[2,3-
d
]pyrimidin-7-one Derivatives as Highly Potent and Efficacious Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Inhibitors for Cancer Treatment
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 5, 页码: 3986-4006
作者:
Sun, Yaoliang
;
Chen, Manman
;
Han, Yuyan
;
Li, Weiqiang
;
Ma, Xiaoyu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2024/05/07
Toxin metalloproteinases exert a dominant influence on pro-inflammatory response and anti-inflammatory regulation in jellyfish sting dermatitis
期刊论文
OAI收割
JOURNAL OF PROTEOMICS, 2024, 卷号: 292, 页码: 13
作者:
Yu, Chunlin
;
Yin, Xiujing
;
Li, Aoyu
;
Li, Rongfeng
;
Yu, Huahua
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/04/07
Jellyfish sting
Metalloproteinase
Differential analysis
Signal pathway
Dermatitis mechanism