中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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期刊论文 [1957]
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Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
作者:
Zeng, Yanping
;
Xiao, Jian
;
Shi, Li
;
Li, Yangsha
;
Xu, Yuanxin
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/04/01
LC3B
CDK9
Degradation
Protein complex
Design of Selective BRD4 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 18
作者:
Yang, Yueyue
;
Liu, Hongli
;
Yuan, Haoxing
;
Lyu, Kaikai
;
Zhong, Haiyang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
Presence and sources of per- and polyfluoroalkyl substances (PFASs) in the three major rivers on Hainan Island
期刊论文
OAI收割
ENVIRONMENTAL RESEARCH, 2025, 卷号: 266, 页码: 15
作者:
Tang, Wang-Qing
;
Wang, Tuan-Tuan
;
Miao, Jiang-Wei
;
Tan, Hua-Dong
;
Zhang, Hong-Jin
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/03
PFASs
Hainan Island
Occurrence
Risk assessment
Rivers
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models
期刊论文
OAI收割
ADVANCED SCIENCE, 2025, 页码: 17
作者:
Cai, Zhixiong
;
Li, Zhenli
;
Zhong, Wenting
;
Lin, Fangzhou
;
Dong, Xiuqing
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/04/01
apCAFs
immunotherapy
mesothelin
neoantigen vaccine
pancreatic cancer
An Enigmatic PeVatron in an Area around HII Region G35.6-0.5
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 979, 期号: 1
作者:
Cao, Zhen
;
Aharonian, F.
;
Axikegu
;
Bai, Y. X.
;
Bao, Y. W.
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/03/24
Unified Astronomy Thesaurus concepts: Gamma-rays (637)
Gamma-ray sources (633)
H II regions (694)
Supernova remnants (1667)
An Enigmatic PeVatron in an Area around H ii Region G35.6−0.5
期刊论文
OAI收割
The Astrophysical Journal, 2025, 卷号: 979, 期号: 1
作者:
Cao,Zhen
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/02/17
Stromatoporoids of the upper Hirnantian (Upper Ordovician) Shiqian Formation of South China: implications for environmental interpretation and the Ordovician-Silurian stromatoporoid transition
期刊论文
OAI收割
JOURNAL OF SYSTEMATIC PALAEONTOLOGY, 2024, 卷号: 22, 期号: 1, 页码: 33
作者:
Jeon, Juwan
;
Kershaw, Stephen
;
Li, Yue
;
Chen, Zhong-Yang
;
Toom, Ursula
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/08/28
Late Ordovician glaciation
Hirnantian
end-Ordovician mass extinction
South China
stromatoporoids
Ordovician-Silurian stromatoporoid transition
π-HuB: the proteomic navigator of the human body
期刊论文
OAI收割
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
作者:
He, Fuchu
;
Aebersold, Ruedi
;
Baker, Mark S.
;
Bian, Xiuwu
;
Bo, Xiaochen
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
Exploration of novel 20S proteasome activators featuring anthraquinone structures and their application in hypoxic cardiomyocyte protection
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 115, 页码: 10
作者:
Yu, Qian
;
Gao, Lixin
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/12/11
Interaction-Based Inductive Bias in Graph Neural Networks: Enhancing Protein-Ligand Binding Affinity Predictions From 3D Structures
期刊论文
OAI收割
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE, 2024, 卷号: 46, 期号: 12, 页码: 8191-8208
作者:
Yang, Ziduo
;
Zhong, Weihe
;
Lv, Qiujie
;
Dong, Tiejun
;
Chen, Guanxing
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/01/14
Proteins
Programmable logic arrays
Three-dimensional displays
Predictive models
Graph neural networks
Data models
Convolution
Protein-ligand binding affinity
graph neural networks
inductive bias
drug-target interaction
structure-based virtual screening