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Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
西北高原生物研究所 [20]
上海生物化学与细胞... [15]
上海药物研究所 [12]
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期刊论文 [134]
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Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24
作者:
Li, Na
;
Wang, Linlin
;
Hu, Xinyuan
;
Xu, Haiyan
;
Yang, Bowen
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Voltage-gated sodium channel 1.8
Conformational restriction
Pharmacokinetic
Structure-activity relationship
Analgesic
Residue-Selective Inhibitors Discovery via Covalent DNA-Encoded Chemical Libraries with Diverse Warheads
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 18, 页码: 15469-15481
作者:
Wu, Xinyuan
;
Pan, Jiayi
;
Fan, Rufeng
;
Zhang, Yiwei
;
Wang, Chao
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2025/06/23
Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14
作者:
Wu, Xinyuan
;
Li, Shunyao
;
Liang, Ting
;
Yu, Qing
;
Zhang, Yiwei
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/06/23
Activity-based protein profiling data
Covalent DNA-encoded chemical library
Covalent ligand selection
Lysine-targeting covalent inhibitors
Precipitation alleviates microbial C limitation but aggravates N and P limitations along a 3000-km transect on the Tibetan Plateau
期刊论文
OAI收割
CATENA, 2024, 卷号: 247, 页码: 108535
作者:
Pan, Junxiao
;
Zhang, Xinyu
;
Liu, Shuang
;
Liu, Ning
;
Liu, Mengjie
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2025/02/24
Alpine grasslands
Enzymatic stoichiometry
Microbial nutrient limitations
Precipitation gradient
Vector model
Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 页码: 14
作者:
Wang, Xudong
;
Xiong, Liwei
;
Zhu, Ying
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/12/25
Enhancing the Predictive Power of Machine Learning Models through a Chemical Space Complementary DEL Screening Strategy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 12
作者:
Suo, Yanrui
;
Qian, Xu
;
Xiong, Zhaoping
;
Liu, Xiaohong
;
Wang, Chao
  |  
收藏
  |  
浏览/下载:117/0
  |  
提交时间:2024/11/26
The seasonal evolution of the Yellow Sea Cold Water Mass Circulation: Roles of fronts, thermoclines, and tidal rectification
期刊论文
OAI收割
OCEAN MODELLING, 2024, 卷号: 190, 页码: 15
作者:
Hu, Yibo
;
Yu, Fei
;
Si, Guangcheng
;
Sun, Fan
;
Liu, Xingchuan
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/09/02
Circulation
Yellow Sea Cold Water Mass
Front
Thermocline
Tidal rectification
Lithium extraction from salt lake brine by four-stage ion-distillation of flow electrode capacitive deionization
期刊论文
OAI收割
CHEMICAL ENGINEERING JOURNAL, 2024, 卷号: 493
作者:
Ma, Guangqiang
;
Zhang, Xinyuan
;
Cai, Anjiang
;
Liu, Fei
;
Wang, Lei
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/11/20
Flow-electrode capacitive deionization
Lithium extraction
Monovalent selectivity membranes
Ion-distillation
Salt lake
Unconscious and Conscious Gaze-Triggered Attentional Orienting: Distinguishing Innate and Acquired Components of Social Attention in Children and Adults with Autistic Traits and Autism Spectrum Disorders
期刊论文
OAI收割
RESEARCH, 2024, 卷号: 7, 页码: 13
作者:
Yang, Fang
;
Tian, Junbin
;
Yuan, Peijun
;
Liu, Chunyan
;
Zhang, Xinyuan
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/08/26
Facile synthesis of pyridazinone-focused DNA-encoded libraries
期刊论文
OAI收割
TETRAHEDRON LETTERS, 2024, 卷号: 142, 页码: 4
作者:
Lv, Yuhan
;
Mu, Baiyang
;
Qin, Shaozhao
;
Wu, Xinyuan
;
Lu, Weiwei
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2024/06/27