中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [185]
近代物理研究所 [57]
昆明植物研究所 [53]
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Pharmacokinetics, mass balance, and metabolism of [
14
C]envonalkib (TQ-B3139), a novel ALK tyrosine kinase inhibitor, in healthy Chinese subjects
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2024, 页码: 11
作者:
Ma, Sheng
;
Wang, Xin
;
Yan, Shu
;
Miao, Liyan
;
Wan, Xiaojing
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2024/05/07
Envonalkib
TQ-B3139
Pharmacokinetics
Mass balance
Excretion
Metabolism
Serial Multiple Mediation of Anxiety and Hostile Attribution Bias in the Relationship Between Need for Uniqueness and Adolescents' Cyberbullying Perpetration: A Two-Wave Study
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF MENTAL HEALTH AND ADDICTION, 2024, 页码: 16
作者:
Wei, Hua
;
Ding, Huimin
;
Huang, Feng
;
Fang, Jiashuai
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/04/15
Need for uniqueness
Anxiety
Hostile attribution bias
Cyberbullying perpetration
A novel strategy for treating oncogene-mutated tumors by targeting tumor microenvironment and synergistically enhancing anti-PD-1 immunotherapy
期刊论文
OAI收割
CANCER COMMUNICATIONS, 2024, 页码: 5
作者:
Liu, Yingqiang
;
Tong, Linjiang
;
Zhang, Mengge
;
Zhang, Qi
;
Liu, Qiupei
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2024/03/13
Efficient Thermoelectric Conversion of Sulfide Chimneys in Submarine Volcanic Systems
期刊论文
OAI收割
EARTH AND SPACE SCIENCE, 2024, 卷号: 11, 期号: 1, 页码: 11
作者:
Jia, Haoning
;
Zhu, Jiaqi
;
Li, Yanzhang
;
Li, Jiwei
;
Ye, Huan
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2024/02/06
From bench to bedside: current development and emerging trend of KRAS-targeted therapy
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 18
作者:
Chen, Yi
;
Liu, Qiu-pei
;
Xie, Hua
;
Ding, Jian
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/01/16
KRAS mutation
KRAS(G12C) inhibitor
Pan-KRAS inhibitor
SHP2 allosteric inhibitor
SOS1 inhibitor
combination therapy
Preclinical and early clinical studies of a novel compound SYHA1813 that efficiently crosses the blood-brain barrier and exhibits potent activity against glioblastoma
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13, 期号: 12, 页码: 4748-4764
作者:
Liu, Yingqiang
;
Zhan, Zhengsheng
;
Kang, Zhuang
;
Li, Mengyuan
;
Lv, Yongcong
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/01/26
Small molecule inhibitor
Tumor microenvironment
Immune-checkpoint
immune-deficient mouse models
including temozolomide (TMZ) insensitive tumors. Notably
Design and synthesis of 1H-pyrazolo[3,4-
d
]pyrimidine derivatives as hematopoietic progenitor kinase 1 (HPK1) inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 140, 页码: 18
作者:
Zhang, Junjie
;
Li, Yan
;
Tang, Haotian
;
Zhou, Qianqian
;
Tong, Linjiang
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2023/12/08
Cancer immunotherapy
HPK1
Structure -based design
HPK1 inhibitor
Reduced soil multifunctionality and microbial network complexity in degraded and revegetated alpine meadows
期刊论文
OAI收割
JOURNAL OF ENVIRONMENTAL MANAGEMENT, 2023, 卷号: 343, 页码: 12
作者:
Wu, Bobo
;
Ding, Mingjun
;
Zhang, Hua
;
Devlin, Adam Thomas
;
Wang, Peng
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2023/10/09
Ecological restoration
Grassland patches
Microbial community assembly
Nutrient availability
Soil structure
The Qinghai-Tibetan plateau
Hepatic glucuronyl C5-epimerase combats obesity by stabilising GDF15
期刊论文
OAI收割
JOURNAL OF HEPATOLOGY, 2023, 卷号: 79, 期号: 3, 页码: 14
作者:
He, Fei
;
Jiang, Haowen
;
Peng, Chang
  |  
收藏
  |  
浏览/下载:61/0
  |  
提交时间:2023/10/17
Glucuronyl C5-epimerase
Growth differentiation factor-15
Obesity
Energy expenditure
Ubiquitination
Design, synthesis and pharmacological evaluation of 2,3-dihydrobenzo-furan IRAK4 inhibitors for the treatment of diffuse large B-cell lymphoma
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 16
作者:
Chen, Yun
;
Ning, Yi
;
Chen, Zhiwei
;
Xue, Yaping
;
Wu, Qingyun
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2023/10/17
Apoptosis
Diffuse large B-Cell lymphoma
Interleukin-1 receptor associated kinase 4
Structure-based drug design
2
3-Dihydrobenzofuran