中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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广州地球化学研究... [173]
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Torque work of origin-destination flows: Quantifying urban place centrality from a physical perspective
期刊论文
OAI收割
COMPUTERS ENVIRONMENT AND URBAN SYSTEMS, 2025, 卷号: 121, 页码: 102311
作者:
Yan, Xiaorui
;
Pei, Tao
;
Song, Ci
;
Fang, Zidong
;
Liu, Xiaohan
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/07/18
Place centrality
Origin-destination flows
Torque work
Multiscale analysis
Intra-day dynamic
Urban science
Design and structural optimization of novel SOS1 inhibitors in KRAS-driven cancers
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 125, 页码: 8
作者:
Chen, Yating
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/08/20
SOS1 inhibitor
KRAS mutation
SOS1-KRAS interaction
Resistance
High-resolution Solar Image Registration Using Unsupervised Deep Learning
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 988, 期号: 2
作者:
Zhang, Hao
;
Liang, Bo
;
Yan XL(闫晓理)
;
Feng, Song
;
Yuan, Ding
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/08/11
Analysis of the shear failure between track slab and CA mortar layer caused by thermal effect for ballastless track
期刊论文
OAI收割
CASE STUDIES IN CONSTRUCTION MATERIALS, 2025, 卷号: 22, 页码: 16
作者:
Zhang, Tao
;
Zhang, Zheyuan
;
Tian, Hongming
;
Lu, Chen
;
Wang, Wei
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/06/27
Ballastless track
CA mortar
Constitutive model
Damage analysis
Discovery of TBK1Molecular Glue Degraders as a Potential Strategy for the Treatment of Autosomal Dominant Polycystic Kidney Disease (ADPKD)
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 12, 页码: 12862-12880
作者:
Guo, Jing
;
Tang, Haotian
;
Zhao, Wenchao
;
Li, Yong
;
Song, Shukai
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
Detection of two TeV gamma-ray outbursts from NGC 1275 by LHAASO
期刊论文
OAI收割
Monthly Notices of the Royal Astronomical Society, 2025, 卷号: 540, 期号: 2, 页码: 1860-1869
作者:
Cao, Zhen
;
Aharonian, F.
;
Axikegu
;
Bai, Y. X.
;
Bao, Y. W.
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/06/23
methods: data analysis
methods: statistical
galaxies: active
galaxies: jets
gamma
rays: general
Formation and evolution of environmentally persistent free radicals in charcoal and soot generated from biomass materials
期刊论文
OAI收割
JOURNAL OF HAZARDOUS MATERIALS, 2025, 卷号: 488, 页码: 11
作者:
Yan, Xu
;
Cao, Tao
;
Chen, Hao
;
Wu, Junhong
;
Xu, Cuncun
  |  
收藏
  |  
浏览/下载:60/0
  |  
提交时间:2025/04/03
Black carbon
Charcoal
Soot
EPFRs
ROS
Gravitational wave astronomy with TianQin
期刊论文
OAI收割
REPORTS ON PROGRESS IN PHYSICS, 2025, 卷号: 88, 期号: 5
作者:
Li, En-Kun
;
Liu, Shuai
;
Torres-Orjuela, Alejandro
;
Chen, Xian
;
Inayoshi, Kohei
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2025/05/26
gravitational wave
astronomy
TianQin
Phosphatidylinositol 4,5-bisphosphate activation mechanism of human KCNQ5
期刊论文
OAI收割
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2025, 卷号: 122, 期号: 14, 页码: 11
作者:
Yang, Zhenni
;
Zheng, Yueming
;
Ma, Demin
;
Wang, Long
;
Zhang, Jiatong
  |  
收藏
  |  
浏览/下载:17/0
  |  
提交时间:2025/06/23
KCNQ
PIP2
ligand activation
structure
mechanism