中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [45]
昆明植物研究所 [21]
西北高原生物研究所 [10]
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期刊论文 [138]
专利 [3]
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2024 [4]
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浏览/检索结果:
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Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H)-one derivatives as potent USP1 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 18
作者:
Li, Hongrui
;
Liu, Ben-Jin
;
Xu, Jiahao
;
Song, Shan-Shan
;
Ba, Ruixian
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/08/22
USP1 inhibitor
Structure -activity relationships
Olaparib-resistant cell
The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity
期刊论文
OAI收割
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2024, 卷号: 716, 页码: 12
作者:
Xuan, Yi-Fei
;
Lu, Shan
;
Ou, Ying-Jie
;
Bao, Xu-Bin
;
Huan, Xia-Juan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/07/12
MAT2A inhibitor
METTL3 inhibitor
m6A
Combination therapy
NSCLC
ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15
作者:
Wang, Le-le
;
Wang, Huan
;
Lin, Si-jin
;
Xu, Xing-yu
;
Hu, Wen-juan
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/07/12
microglial inflammation
BD2
ABBV-744
BATF2
IRF4
JAK/STAT
Co-inhibition of BET and NAE enhances BIM-dependent apoptosis with augmented cancer therapeutic efficacy
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2024, 卷号: 223, 页码: 17
作者:
Zhang, Qian
;
Wu, Qian
;
Huan, Xia-Juan
;
Song, Shan -Shan
;
Bao, Xu-Bin
  |  
收藏
  |  
浏览/下载:24/0
  |  
提交时间:2024/06/27
BET inhibitor
NAE inhibitor
BIM
Apoptosis
Combination therapy
Proteasome inhibitors reduce CD73 expression partly
via
decreasing p-ERK in NSCLC cells
期刊论文
OAI收割
LIFE SCIENCES, 2023, 卷号: 332, 页码: 10
作者:
Su, Ai-Ling
;
Tian, Chang-Qing
;
Ou, Ying-Jie
;
Bao, Xu-Bin
;
Huan, Xia-Juan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/12/08
CD73
Proteasome inhibitors
ERK
NSCLC
Tropical ocean temperatures and changes in terrigenous flux during the Paleocene-Eocene Thermal Maximum in southern Tibet
期刊论文
OAI收割
GLOBAL AND PLANETARY CHANGE, 2023, 卷号: 230, 页码: 14
作者:
Jin, Simin
;
Li, Guobiao
;
Li, Juan
;
Hu, Xiumian
;
Yang, Huan
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2024/03/14
PETM
Carbonate platform
Paleoclimate
Sea level
Carbon isotopes
GDGT
Bispecific antibody targeting both B7-H3 and PD-L1 exhibits superior antitumor activities
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 9
作者:
Li, Hua-ying
;
Chen, Yi-li
;
Deng, Xiang-nan
;
Li, Huan-huan
;
Tan, Jie
  |  
收藏
  |  
浏览/下载:42/0
  |  
提交时间:2023/10/17
cancer immunotherapy
B7-H3
PD-L1
bispecific antibodies
VHH
antibody-dependent cell-mediated cytotoxicity (ADCC)
Thioparib inhibits homologous recombination repair, activates the type I IFN response, and overcomes olaparib resistance
期刊论文
OAI收割
EMBO MOLECULAR MEDICINE, 2023, 页码: 24
作者:
Wang, Li-Min
;
Wang, Pingyuan
;
Chen, Xiao-Min
;
Yang, Hui
;
Song, Shan-Shan
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2023/04/10
homologous recombination repair
olaparib-resistant
PARP inhibitor
PARP7
type I interferons
Labdane diterpenoids from the heartwood of Leucosceptrum canum that impact on root growth and seed germination of Arabidopsis thaliana
期刊论文
OAI收割
PHYTOCHEMISTRY, 2023, 卷号: 206, 页码: 113531
作者:
Liu,Yan
;
Zhou,Yan-Ying
;
Luo,Shi-Hong
;
Guo,Kai
;
Zhang,Man-Wen
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/07/22
Leucosceptrum canum
Lamiaceae
Labdane diterpenoids
Leucolactones A-K
Phytotoxic activity
Auxin accumulation
GLANDULAR TRICHOMES
COLORED NECTAR
AUXIN
TRANSPORT
GRADIENT
WOOD
Isolation and identification of hemostatic steroidal glycosides from Ypsilandra thibetica
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 106268
作者:
Ma,Wen-Yi
;
Xie,Jing
;
Yu,Ling-Ling
;
Zhang,Shi-Juan
;
Ni,Wei
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/07/22
Ypsilandra thibetica
Steroidal saponins
Ypsilandrosides Z1-Z14
Hemostatic activity
Structure-activity relationship
SPIROSTANE GLYCOSIDES
NMR-SPECTROSCOPY
AGGREGATION
SAPOGENINS
SAPONINS