中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Pharmacokinetics, mass balance, and metabolism of [
14
C]PLB1004, a selective and irreversible EGFR-TKI in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 14
作者:
Liu, Donghui
;
Li, Qian
;
Yan, Shu
;
Zhang, Xinyue
;
Li, Weiqiang
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2025/04/01
PLB1004
[C-14]PLB1004
Radioactivity
Mass balance
EGFR-TKI
Pharmacokinetics, mass balance, and metabolism of [
14
C]FCN-437c, a selective and potent CDK4/6 inhibitor in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 12
作者:
Gao, Lei
;
Ma, Sheng
;
Yan, Shu
;
Zhang, Hua
;
Tian, Ling
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/07/25
FCN-437c
CDK4/6 inhibitor
Mass balance
Radiopharmacokinetics
Drug metabolism
Microplastics decrease soil compressibility but have no major impact on soil physical properties
期刊论文
OAI收割
SOIL & TILLAGE RESEARCH, 2025, 卷号: 253, 页码: 106688
作者:
Dong, Yuhao
;
Ren, Lidong
;
Jia, Xiaoxu
;
Liao, Xiaoyong
;
Huang, Laiming
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/07/18
Uniaxial compression test
Microplastic shapes
Soil structure
Soil compaction
X-ray micro-CT
A spatio-temporal fusion method for non-destructive testing using infrared thermography
期刊论文
OAI收割
OPTICS AND LASERS IN ENGINEERING, 2025, 卷号: 194, 页码: 14
作者:
Huang XF(黄晓芙)
;
Hou XY(侯星宇)
;
Wang, Puxiang
;
Zhao, Dong
;
Zhao, Jian
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/08/18
Infrared thermography
Spatio-temporal fusion thermography
Linear laser thermography
Optical flow method
Surface defects
Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Superior peroxidase-like activities of InVO
4
hollow nanocuboid assemblies for colorimetric detection of hydrogen peroxide and glucose
期刊论文
OAI收割
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2025, 卷号: 338, 页码: 11
作者:
Chen, Juna
;
Hu, Jingfei
;
Chi, Jingtian
;
Hou, Peng
;
Zhang, Wanwan
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2025/07/11
Peroxidase mimics
Nanozyme
Colorimetric detection
Biosensor
InVO4
Transboundary impacts of microplastics within planetary boundaries: Regulation and responses of soil-plant systems under climate change
期刊论文
OAI收割
ENVIRONMENTAL RESEARCH, 2025, 卷号: 282, 页码: 122080
作者:
Lu, Gaoyu
;
Wang, Zhirong
;
Wang, Junbang
;
Zhang, Xiujuan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/07/18
Microplastics
Climate change
Soil-plant systems
Planetary boundaries
Ecotoxicity
Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CL
pro
inhibitors against SARS-CoV-2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11
作者:
Guma, Samuel Desta
;
Song, Kang
;
Sun, Haiguo
;
Yang, Lei
;
Zhou, Zhaoyin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
SARS-CoV-2
3CL(pro) inhibitors
Thioamide derivatives
Spiropyrrolidine derivatives
Nirmatrelvir
HCoV-OC43
Antiviral
Metabolic stability
Kadcoccinoids A-K, triterpenoids from
Kadsura coccinea
with PCSK9 expression inhibitory activities
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 238, 页码: 13
作者:
Duan, Yelin
;
Chen, Tong
;
Guo, Pengju
;
Li, Chenyue
;
Chen, Yihan
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Kadsura coccinea
Schisandraceae
Lanostane-type triterpenoids
Protostane-type triterpenoids
PCSK9
Discovery of indole derivatives as STING degraders
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 21
作者:
An, Yuxiang
;
Zhang, Yan
;
Luo, Xin
;
Lan, Yaohan
;
Geng, Meiyu
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Autoimmune diseases
Degrader
Inflammatory
PROTAC
STING