中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [66]
西北高原生物研究所 [18]
地理科学与资源研究... [13]
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共147条,第1-10条
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A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY
期刊论文
OAI收割
THERANOSTICS, 2025, 卷号: 15, 期号: 10, 页码: 4325-4344
作者:
Zhang, Zhidan
;
Chen, Meijie
;
Xu, Yitong
;
Wang, Zhihua
;
Liu, Zhenghong
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收藏
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浏览/下载:0/0
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提交时间:2025/06/23
Atherosclerosis
Hyperlipidemia
ATP-Citrate lyase (ACLY)
lipid metabolism
Isoginkgetin
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794
作者:
Liu, Yun
;
Yu, Chengyin
;
Zhang, Yifan
;
Xie, Zhifu
;
Wang, Yating
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收藏
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浏览/下载:0/0
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提交时间:2025/04/24
safety
tolerability
pharmacokinetics
pharmacodynamics
BGT-002
novel ACLY inhibitor
Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 16
作者:
Nie, Hui-Jun
;
Li, Ben-Fu
;
Sun, Jingya
;
Yuan, Yali
;
Zhang, Zhi-Gao
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/11/26
Triple-negative breast cancer
Targeting transcription regulation
Orally bioavailable degrader
PROTAC
Cyclin-dependent Kinase 9
Discovery of Alkyl Conjugated Diene Diacids as Novel ACLY Inhibitors
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 11, 页码: 3476-3489
作者:
Cheng, Tingting
;
Song, Gaolei
;
Cheng, Long
;
Wang, Fan
;
Sun, Xinyu
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收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/02/28
metabolic diseases
ATP-citrate lyase (ACLY)
lipogenesis
ACLY inhibitors
dienyldicarboxylic acid
Wind erosion prevention and trans-boundary ecosystem service payments in the Hunshandake region
期刊论文
OAI收割
JOURNAL OF CLEANER PRODUCTION, 2024, 卷号: 475, 页码: 143664
作者:
Huang, Mengdong
;
Xiao, Yu
;
Zhang, Changshun
;
Zhen, Lin
;
Qin, Keyu
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/10/21
Ecosystem services flow
Wind erosion prevention service
Ecosystem service payment
Trans-boundary payment
Ecological fiscal transfers
Simultaneous determination of BGT-002 and its acyl glucuronide metabolite ZM326E-M2 in human plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8
作者:
Zhu, Xueran
;
Cui, Shumin
;
Liu, Xinjing
;
Zhang, Mei
;
Xie, Zhifu
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/31
ATP-Citrate Lyase
BGT-002
Acyl glucuronide metabolite
Pseudo-MRM
LC-MS/MS
Pharmacokinetics
Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity
期刊论文
OAI收割
BIOMOLECULES, 2024, 卷号: 14, 期号: 6, 页码: 21
作者:
Wen, Xueping
;
Song, Yufei
;
Zhang, Mei
;
Kang, Yiping
;
Chen, Dandan
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收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/08/22
18a
adipocytes
polyphenols
thermogenesis
UCP1
Exploring the Structural Plasticity Mechanism of Corticospinal Tract during Stroke Rehabilitation Based Automated Fiber Quantification Tractography
期刊论文
OAI收割
NEUROREHABILITATION AND NEURAL REPAIR, 2024, 页码: 12
作者:
Zhang, Haojie
;
Zhao, Jun
;
Fan, Lingzhong
;
Wu, Xia
;
Li, Fang
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收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/30
automated fiber quantification
corticospinal tract
MRI
rehabilitation
stroke
structural plasticity
DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser
56
to diminish pancreatic β cell function upon overnutrition
期刊论文
OAI收割
SCIENCE TRANSLATIONAL MEDICINE, 2024, 卷号: 16, 期号: 733, 页码: 16
作者:
Lu, Yuting
;
Xu, Junyu
;
Li, Yufeng
;
Wang, Ruoran
;
Dai, Chengqiu
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收藏
  |  
浏览/下载:42/0
  |  
提交时间:2024/03/13
Increased frequency of extreme climatic events weakens the community stability of natural grassland under directional climate changes by reducing resilience
期刊论文
OAI收割
GLOBAL ECOLOGY AND BIOGEOGRAPHY, 2024, 卷号: 33, 期号: 6
作者:
Liu, Peipei
;
Lv, Wangwang
;
Sun, Jianping
;
Piao, Shilong
;
Wang, Yanfen
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收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/11/27