中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [178]
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OAI收割 [418]
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期刊论文 [409]
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Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 12
作者:
Wu, Feifei
;
Sun, Jiaqi
;
Xu, Mingyang
;
Li, Huiyu
;
Wei, Jiarui
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Macrocycle
Kinase
Inhibitors
HPK1
Cancer immunotherapy
An overview of PROTACs targeting KRAS and SOS1 as antitumor agents
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2025, 卷号: 125, 页码: 13
作者:
Han, Zhiqiu
;
Wu, Qianping
;
Rao, Hongxin
;
Xu, Tianfeng
;
Zhou, Chuan
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
KRAS
SOS1
PROTAC
Antitumor agent
Immunosuppressive nitrogen-containing triterpenoid saponins from
Mussaenda
erosa
and the therapeutic efficacy of heinsiagenin A in a murine lupus erythematosus model
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 11
作者:
Xu, Yidan
;
Xiang, Mai
;
Chang, Yuan
;
Chen, Zhenhua
;
Zhang, Rujun
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Mussaenda erosa
Nitrogen-containing triterpenoid saponins
Immunosuppressive activity
Autoimmune diseases
Heinsiagenin A
UBE4B modulates BET inhibitor sensitivity via KLHL22-JAK2-PIM1 axis in hepatocellular carcinoma
期刊论文
OAI收割
BIOCHEMICAL PHARMACOLOGY, 2025, 卷号: 237, 页码: 19
作者:
Wang, Li
;
Huan, Xia-Juan
;
Song, Shan-Shan
;
Bao, Xu-Bin
;
Tian, Chang-Qing
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/06/23
UBE4B
BET inhibitors
Resistance
KLHL22
JAK2
Design and synthesis of GRPR-targeted PET probes based on Dar derivatives for imaging of prostate cancer
期刊论文
OAI收割
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2025, 卷号: 67, 页码: 9
作者:
Luo, Xiangning
;
Luo, Renli
;
Zhou, Yuanyuan
;
Jiang, Yuanpeng
;
Han, Cong
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/08/20
Gastrin-releasing peptide receptor
68Ga
Dar chelator
Positron emission tomography
Imaging probe
Methotrexate exerts antitumor immune activity and improves the clinical efficacy of immunotherapy in patients with solid tumors
期刊论文
OAI收割
SCIENCE TRANSLATIONAL MEDICINE, 2025, 卷号: 17, 期号: 801, 页码: 18
作者:
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
Enhanced Bioactivity of Natural Products by Halogenation: A Database Survey and Quantum Chemistry Calculation Study
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 10, 页码: 10486-10496
作者:
Cao, Ruini
;
Li, Jintian
;
Liao, Qingyi
;
Shao, Mei
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/07/25
Discovery of novel antimyeloma agents targeting TRIP13 by molecular modeling and bioassay
期刊论文
OAI收割
RSC MEDICINAL CHEMISTRY, 2025, 页码: 14
作者:
Bunu, Samuel Jacob
;
Cai, Haiyan
;
Zhou, Zhaoyin
;
Zhang, Yanlei
;
Lai, Yue
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/06/23
Detection of an Orphan X-Ray Flare from a Blazar Candidate EP240709a with the Einstein Probe
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 984, 期号: 1
作者:
Liu, Mingjun
;
Zhang, Yijia
;
Wang, Yun
;
Xue, Rui
;
Buckley, David
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2025/05/05
The combination of BET and METTL3 inhibitors elicits synergistic antitumor effects in ovarian cancer cells
via
reducing SP1 and BCL-2 expression
期刊论文
OAI收割
LIFE SCIENCES, 2025, 卷号: 368, 页码: 14
作者:
Ou, Ying-Jie
;
Liu, Ben-Jin
;
Xuan, Yi-Fei
;
Bao, Xu-Bin
;
Huan, Xia-Juan
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/04/24
BET inhibitor
METTL3 inhibitor
Combination therapy
SP1
BCL-2