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浏览/检索结果: 共113条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择提交时间升序提交时间降序作者升序作者降序题名升序题名降序发表日期升序发表日期降序 Structural optimization of phthalazine derivatives for anti-HBV activities to improve oral bioavailability 期刊论文  OAI收割 BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 10 作者:  Yang, Yurong;  Xiao, Fuling;  Zuo, Jianping;  Yang, Li;  Hu, Youhong   |  收藏  |  浏览/下载：2/0  |  提交时间：2025/08/20 HBV  Capsid assembly modulators  Structural optimization  Oxidative metabolism   Design and synthesis of CDK9/EZH2 dual-target inhibitors to achieve synergistic antitumor effects 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 14 作者:  Tian, Lina;  Xiao, Jian;  Zeng, Yanping;  Li, Yangsha;  Wei, Aihuan   |  收藏  |  浏览/下载：3/0  |  提交时间：2025/08/20 CDK9  EZH2  Dual target inhibitor  DLBCL   Discovery of potent anti-idiopathic pulmonary fibrosis (IPF) agents based on an o-aminopyridinyl alkynyl scaffold 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 15 作者:  Wang, Yang;  Fan, Wenhui;  Guo, Yihao;  Sun, Li;  Hu, Youhong   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/08/20 IPF  EMT  Key kinases  Inhibitors   Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10 作者:  Zeng, Yanping;  Xiao, Jian;  Shi, Li;  Li, Yangsha;  Xu, Yuanxin   |  收藏  |  浏览/下载：78/0  |  提交时间：2025/04/01 LC3B  CDK9  Degradation  Protein complex   Single Amine or Guanidine Modification on Norvancomycin and Vancomycin to Overcome Multidrug-Resistance through Augmented Lipid II Binding and Increased Membrane Activity 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20639-20663 作者:  Bian, Xiaolei;  Chen, Zhifu;  Li, Fang;  Xie, Yuanyuan;  Li, Yi   |  收藏  |  浏览/下载：26/0  |  提交时间：2024/12/11 Analysis of near-well hydraulic fracture propagation behavior in inhomogeneous deep-sea hydrate-bearing-sediments 期刊论文  OAI收割 GEOENERGY SCIENCE AND ENGINEERING, 2024, 卷号: 242, 页码: 15 作者:  Liu, Jinxin;  Yu, Yongping;  Ma, Xiaolong;  Sun, Youhong;  Li, Bing   |  收藏  |  浏览/下载：9/0  |  提交时间：2025/06/27 Inhomogeneous hydrate reservoir  Disseminated hydrates  Extended finite element method  Hydraulic fracturing   A novel phthalazinone derivative as a capsid assembly modulator inhibits hepatitis B virus expression 期刊论文  OAI收割 ANTIVIRAL RESEARCH, 2024, 卷号: 221, 页码: 14 作者:  Yang, Li;  Gong, Ying;  Liu, Feifei;  Chen, Wuhong;  Wang, Xinran   |  收藏  |  浏览/下载：50/0  |  提交时间：2024/02/19 Hepatitis B virus  Capsid assembly  Phthalazinone derivatives  Apoptosis   A prodrug of the capsid assembly modulator improved druggability and lowing HBsAg and HBeAg for the treatment of chronic hepatitis B 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 8 作者:  Chen, Wuhong;  Gong, Ying;  Long, Guozhang;  Wang, Xinran;  Yang, Yurong   |  收藏  |  浏览/下载：39/0  |  提交时间：2023/10/17 HBV  Capsid assembly modulators  Prodrug  Hepatitis B surface antigen   Discovery of (S)-N-(2-Amino-4-fluorophenyl)-4-(1-(3-(4-((dimethylamino)methyl)phenyl)-6-oxopyridazin-1(6H)-yl)ethyl)benzamide as Potent Class I Selective HDAC Inhibitor for Oral Anticancer Drug Candidate 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 66, 期号: 10, 页码: 7016-7037 作者:  Li, Daqiang;  Zhang, Zhuo;  Li, Yalei;  Wang, Xinyi;  Zhong, Hanyue   |  收藏  |  浏览/下载：32/0  |  提交时间：2023/10/17 Discovery of potent ebola entry inhibitors with (3S,4aS,8aS)-2-(3-amino-2-hydroxypropyl) decahydroisoquinoline-3-carboxamide scaffold 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 240, 页码: 12 作者:  Han, Sheng;  Li, Heng;  Chen, Weixiong   |  收藏  |  浏览/下载：41/0  |  提交时间：2022/11/11 Ebola virus  Entry inhibitor  Structural optimization