机构

• 合肥物质科学研究院 [36]
• 地球化学研究所 [4]
• 高能物理研究所 [3]
• 近代物理研究所 [2]
• 上海药物研究所 [1]
• 寒区旱区环境与工程研... [1]
• 更多

采集方式

• OAI收割 [49]
• iSwitch采集 [1]

内容类型

• 期刊论文 [50]

发表日期

• 2023 [1]
• 2022 [1]
• 2021 [2]
• 2020 [2]
• 2019 [4]
• 2018 [4]
• 更多

学科主题

• 环境地球化学 [2]
• 物理科学和化学 [1]

筛选

浏览/检索结果: 共50条，第1-10条 帮助 条数/页： 5101520253035404550556065707580859095100 排序方式： 请选择题名升序题名降序提交时间升序提交时间降序作者升序作者降序发表日期升序发表日期降序 Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2023, 卷号: 13 作者:  Hua, Chen;  Shena, Lijuan;  Zoua, Fengming;  Wua, Yun;  Wanga, Beilei   |  收藏  |  浏览/下载：11/0  |  提交时间：2023/11/10 Acquired resistance mutations  CDK9 inhibitors  Transcription  Single nucleotide polymorphisms  BAY1251152   Discovery of Pyrrolo[2,3-d]pyrimidine derivatives as potent and selective colony stimulating factor 1 receptor kinase inhibitors 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 243 作者:  Liang, Xiaofei;  Wang, Chun;  Wang, Beilei;  Liu, Juan;  Qi, Shuang   |  收藏  |  浏览/下载：39/0  |  提交时间：2022/12/23 CSF1R inhibitor  Kinase inhibitor  Macrophage polarization   DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing 期刊论文  OAI收割 CELL METABOLISM, 2021, 卷号: 33, 期号: 10, 页码: 2004-+ 作者:  Li, Yufeng;  Xu, Junyu;  Lu, Yuting;  Bian, Hua;  Yang, Lin   |  收藏  |  浏览/下载：49/0  |  提交时间：2022/01/18 Selectively targeting FLT3-ITD mutants over FLT3-wt by a novel inhibitor for acute myeloid leukemia 期刊论文  OAI收割 HAEMATOLOGICA, 2021, 卷号: 106 作者:  Wang, Aoli;  Hu, Chen;  Chen, Cheng;  Liang, Xiaofei;  Wang, Beilei   |  收藏  |  浏览/下载：46/0  |  提交时间：2021/04/26 Discovery of a highly selective VEGFR2 kinase inhibitor CHMFL-VEGFR2-002 as a novel anti-angiogenesis agent 期刊论文  OAI收割 ACTA PHARMACEUTICA SINICA B, 2020, 卷号: 10 作者:  Jiang, Zongru;  Wang, Li;  Liu, Xuesong;  Chen, Cheng;  Wang, Beilei   |  收藏  |  浏览/下载：44/0  |  提交时间：2020/11/26 Cancer  VEGFR2 kinase  Kinase inhibitor  Angiogenesis  Inhibitor selectivity   Discovery of 6 '-chloro-N-methyl-5 '-(phenylsulfonamido)-[3,3 '-bipyridine]-5-carboxamide (CHMFL-PI4K-127) as a novel Plasmodium falciparum PI(4)K inhibitor with potent antimalarial activity against both blood and liver stages of Plasmodium 期刊论文  OAI收割 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 188 作者:  Liang, Xiaofei;  Jiang, Zongru;  Huang, Zhenghui;  Li, Feng;  Chen, Cheng   |  收藏  |  浏览/下载：37/0  |  提交时间：2020/11/26 PI4K kinase  Kinase inhibitor  Malaria  Blood stage  Liver stage   Discovery and characterization of a novel highly potent and selective type II native and drug-resistant V299L mutant BCR-ABL inhibitor (CHMFL-ABL-039) for Chronic Myeloid Leukemia (CML) 期刊论文  OAI收割 CANCER BIOLOGY & THERAPY, 2019, 卷号: 20, 期号: 6, 页码: 877-885 作者:  Wu, Jiaxin;  Wang, Aoli;  Li, Xixiang;  Chen, Cheng;  Qi, Ziping   |  收藏  |  浏览/下载：76/0  |  提交时间：2019/11/27 BCR-ABL  PDGFR  chronic myeloid leukemia  kinase inhibitor   Solving the storm split-merge problem-A combined storm identification, tracking algorithm 期刊论文  iSwitch采集 ATMOSPHERIC RESEARCH, 2019, 卷号: 218, 页码: 335-346 作者:   收藏  |  浏览/下载：61/0  |  提交时间：2019/10/09 Storm identification  Storm tracking  Split-merge  Algorithm evaluation   Discovery of N-(4-(6-Acetamidopyrimidin-4-yloxy)phenyl)-2-(2-(trifluoromethyl)phenyl)acetamide (CHMFL-FLT3-335) as a Potent FMS-like Tyrosine Kinase 3 Internal Tandem Duplication (FLT3-ITD) Mutant Selective Inhibitor for Acute Myeloid Leukemia 期刊论文  OAI收割 JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 2, 页码: 875-892 作者:  Liang, Xiaofei;  Wang, Beilei;  Chen, Cheng;  Wang, Aoli;  Hu, Chen   |  收藏  |  浏览/下载：34/0  |  提交时间：2020/05/21 Repurposing cabozantinib to GISTs: Overcoming multiple imatinib-resistant cKIT mutations including gatekeeper and activation loop mutants in GISTs preclinical models 期刊论文  OAI收割 CANCER LETTERS, 2019, 页码: 105-114 作者:  Lu, Tingting;  Chen, Cheng;  Wang, Aoli;  Jiang, Zongru;  Qi, Ziping   |  收藏  |  浏览/下载：32/0  |  提交时间：2020/07/14 cKIT T670I mutant  Activation loop mutants  Drug resistance