中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [30]
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期刊论文 [99]
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材料科学与物理化学 [3]
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浏览/检索结果:
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679
作者:
Jin, Yuheng
;
Qi, Xuxin
;
Yu, Xiaoli
;
Cheng, Xirui
;
Chen, Boya
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/06/23
HDAC7
PROTAC
Selectivity
Hematologic malignancies
Non-enzymatic function
Discovery of KW0113 as a First and Effective PROTAC Degrader of DNMT1 Protein
期刊论文
OAI收割
CHEMMEDCHEM, 2024, 页码: 16
作者:
Wang, Huihui
;
Wang, Zhaoliang
;
Hu, Linghao
;
Yang, Bingjie
;
Zong, Liangyi
  |  
收藏
  |  
浏览/下载:31/0
  |  
提交时间:2024/12/16
Degrader
DNMT1
DNA methylation
PROTAC
Discovery of a Highly Potent, Selective and Efficacious USP7 Degrader for the Treatment of Acute Lymphoblastic Leukemia
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 20
作者:
Xu, Miaomiao
;
Fu, Jingfeng
;
Pei, Yuan
;
Li, Mengna
;
Kan, Weijuan
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/08/22
Design, Synthesis, and Biological Evaluation of 2,4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors
期刊论文
OAI收割
ACS MEDICINAL CHEMISTRY LETTERS, 2024, 页码: 8
作者:
Zhang, Hualin
;
Tu, Yutong
;
Tao, Zhaofan
;
Gao, Lixin
;
Huang, Shengjie
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/08/22
CDK7 inhibitor
2,4-diaminopyrimidine
selectivity
anticancer
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 28
作者:
Duan, Haiting
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2024/08/20
Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 21
作者:
Lu, Yang
;
Gao, Jian
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/07/12
Hepatocellular carcinoma
Ubiquitin-specific protease 10
Deubiquitination
Selectivity
Structured diary introspection training: A kind of critical thinking training method can enhance the Pro-C creativity of interior designers
期刊论文
OAI收割
THINKING SKILLS AND CREATIVITY, 2024, 卷号: 52, 页码: 14
作者:
Li, Hao
;
Yang, Liu
;
Wang, Ting
;
Xiao, Ruoyu
;
Song, Lili
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/06/29
Critical thinking
Pro -C creativity
Interior designers
Structured diary introspection training method
Integrative proteogenomic and pharmacological landscape of acute myeloid leukaemia
期刊论文
OAI收割
SCIENCE BULLETIN, 2024, 卷号: 70, 期号: 7, 页码: 1051-1056
作者:
Wang, Hanlin
;
Tang, Gusheng
;
Ye, Yunfei
;
Li, Jia
;
Xu, Jun-Yu
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/06/04
Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia
期刊论文
OAI收割
CHEMICAL SCIENCE, 2024, 卷号: 15, 期号: 13, 页码: 5027-5035
作者:
Shi, Yunkai
;
Liu, Minmin
;
Li, Mengna
;
Mao, Yiwen
;
Ma, Jingkun
  |  
收藏
  |  
浏览/下载:51/0
  |  
提交时间:2024/05/07