中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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地质与地球物理研究... [39]
上海硅酸盐研究所 [13]
东北地理与农业生态... [11]
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期刊论文 [182]
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Novel Aryl Sulfonium Modification on Vancomycin to Tackle MRSA and VRE In Vitro and In Vivo through Dual Enhanced Cell-Wall and Membrane Inhibition
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 8, 页码: 8310-8329
作者:
Xie, Yuanyuan
;
Wang, Xiaowen
;
Chang, Taopeng
;
Chen, Zhifu
;
Luo, Youhong
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收藏
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浏览/下载:2/0
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提交时间:2025/06/23
A Rationally Designed Sulfonium Lipoglycopeptide with Micelles Self-Assembly to Combat Multidrug Resistance via Dual Enhanced Cell Wall-Membrane Inhibition and T7SS Proteins Downregulation
期刊论文
OAI收割
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2025, 卷号: 147, 期号: 15, 页码: 12587-12603
作者:
Xie, Yuanyuan
;
Wang, Xiaowen
;
Li, Fang
;
Chen, Zhifu
;
Li, Qun
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收藏
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浏览/下载:1/0
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提交时间:2025/05/27
A natural small molecule isoginkgetin alleviates hypercholesterolemia and atherosclerosis by targeting ACLY
期刊论文
OAI收割
THERANOSTICS, 2025, 卷号: 15, 期号: 10, 页码: 4325-4344
作者:
Zhang, Zhidan
;
Chen, Meijie
;
Xu, Yitong
;
Wang, Zhihua
;
Liu, Zhenghong
  |  
收藏
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浏览/下载:0/0
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提交时间:2025/06/23
Atherosclerosis
Hyperlipidemia
ATP-Citrate lyase (ACLY)
lipid metabolism
Isoginkgetin
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects
期刊论文
OAI收割
DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794
作者:
Liu, Yun
;
Yu, Chengyin
;
Zhang, Yifan
;
Xie, Zhifu
;
Wang, Yating
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/04/24
safety
tolerability
pharmacokinetics
pharmacodynamics
BGT-002
novel ACLY inhibitor
Single Amine or Guanidine Modification on Norvancomycin and Vancomycin to Overcome Multidrug-Resistance through Augmented Lipid II Binding and Increased Membrane Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20639-20663
作者:
Bian, Xiaolei
;
Chen, Zhifu
;
Li, Fang
;
Xie, Yuanyuan
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2024/12/11
Discovery of Alkyl Conjugated Diene Diacids as Novel ACLY Inhibitors
期刊论文
OAI收割
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 11, 页码: 3476-3489
作者:
Cheng, Tingting
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收藏
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浏览/下载:9/0
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提交时间:2025/02/28
metabolic diseases
ATP-citrate lyase (ACLY)
lipogenesis
ACLY inhibitors
dienyldicarboxylic acid
The Effect of Impact Load on the Atomistic Scale Fracture Behavior of Nanocrystalline bcc Iron
期刊论文
OAI收割
NANOMATERIALS, 2024, 卷号: 14, 期号: 4, 页码: 11
作者:
Zhao, Zhifu
;
Wang, Zhen
;
Bie, Yehui
;
Liu, Xiaoming
;
Wei, Yueguang
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收藏
  |  
浏览/下载:19/0
  |  
提交时间:2024/04/02
molecular dynamics simulation
nanocrystalline iron
impact load
fracture resistance
fracture ductility
Fast Radio Bursts: Electromagnetic Counterparts to Extreme Mass-ratio Inspirals
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2023, 卷号: 956, 期号: 1, 页码: L2
作者:
Li, Rui-Nan
;
Zhao, Zhen-Yin
;
Gao, Zhifu
;
Wang, Fa-Yin
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收藏
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浏览/下载:0/0
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提交时间:2024/01/10
Chemical Weathering Intensity as a Reliable Indicator for Southwest Summer Monsoon Reconstruction: Evidence From Clay Minerals of Qionghai Lake Sediments Since the Last Glacial Maximum
期刊论文
OAI收割
GEOCHEMISTRY GEOPHYSICS GEOSYSTEMS, 2023, 卷号: 24, 期号: 7, 页码: 17
作者:
Yu, Xiaoli
;
Wang, Gen
;
Zhang, Ting
;
Ma, Xueyun
;
Zhang, Xiaomei
  |  
收藏
  |  
浏览/下载:29/0
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提交时间:2024/01/02
clay mineral
chemical weathering intensity
southwest summer monsoon
Last Glacial Maximum
Holocene
Influence of the Late Ordovician-Early Silurian Paleoenvironment and Related Geological Processes on the Organic Matter Accumulation and Carbon Isotope Excursion
期刊论文
OAI收割
PALEOCEANOGRAPHY AND PALEOCLIMATOLOGY, 2023, 卷号: 38, 期号: 7, 页码: 22
作者:
Zhang, Pengyuan
;
Wang, Yongli
;
Wei, Zhifu
;
Wang, Gen
;
Zhang, Ting
  |  
收藏
  |  
浏览/下载:18/0
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提交时间:2024/01/02