中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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期刊论文 [2089]
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Development of novel epoxyketone macrocyclic peptidyl proteasome inhibitors through OPA-mediated one-step cyclization of unprotected peptides
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 156, 页码: 16
作者:
Zeng, Gongruixue
;
Xu, Gaoya
;
Gao, Lixin
;
Zheng, Xiaoli
;
Chi, Xinglong
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
Proteasome inhibitors
Macrocycle
Stability
Anti-cancer activities
Terrestrial ecosystem response to Early Cretaceous global environmental change: A calibrated, high-resolution Aptian record from Northeast China
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2025, 卷号: 653, 页码: 13
作者:
Sun, Ming-Dao
;
Lin, Qin
;
Ramezani, Jahandar
;
Liu, Jiang-Si
;
Lu, Zheng-An
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/03
Early Cretaceous
Aptian
CA-ID-TIMS geochronology
Astrochronology
Carbon isotope stratigraphy
Design, synthesis and biological evaluation of Alisol B derivatives for potential treatment of non-alcoholic steatohepatitis
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 155, 页码: 15
作者:
Yu, Nai-Rong
;
Huang, Suling
;
Deng, Zhen-Tao
;
Wang, Jiayue
;
Shen, Yu
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
Non-alcoholic steatohepatitis (NASH)
Alisol B
Structural modification
Structure-activity relationship
HFD+CCl4-induced NASH mice model
Upper Ordovician conodonts from the Taoqupo section in the southwestern margin of the North China Craton
期刊论文
OAI收割
PALAEOWORLD, 2025, 卷号: 34, 期号: 1, 页码: 19
作者:
Li, Shi-Xiao
;
Jing, Xiu-Chun
;
Zhou, Hong-Rui
;
Wang, Xun-Lian
;
Shen, Yang
  |  
收藏
  |  
浏览/下载:15/0
  |  
提交时间:2025/03/28
Conodont biostratigraphy
Sandbian
Katian
Late Ordovician
North China Platform
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 19
作者:
Yin, Wen
;
Xu, Heng
;
Bai, Zhonghao
;
Wu, Yue
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/04/01
Rapid rise in atmospheric CO
2
marked the end of the Late Palaeozoic Ice Age
期刊论文
OAI收割
NATURE GEOSCIENCE, 2025, 卷号: 18, 期号: 1, 页码: 8
作者:
Jurikova, Hana
;
Garbelli, Claudio
;
Whiteford, Ross
;
Reeves, Theodore
;
Laker, Gemma M.
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/03/28
AlphaFold3 versus experimental structures: assessment of the accuracy in ligand-bound G protein-coupled receptors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
作者:
He, Xin-heng
;
Li, Jun-rui
;
Shen, Shi-yi
;
Xu, H. Eric
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/01/14
AlphaFold
structure-based drug design
artificial intelligence
GPCR
structural biology
Differentiated growth of the most widely planted conifer in response to extreme droughts across semi-arid regions in Northern China
期刊论文
OAI收割
AGRICULTURAL AND FOREST METEOROLOGY, 2024, 卷号: 358, 页码: 11
作者:
Li, Jitang
;
Xie, Yuyang
;
Wulan, Tuya
;
Gong, Jie
;
Liu, Hongyan
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2024/12/30
Drought events
Tree-ring analysis
Growth resilience
Pine plantations
Pinus sylvestris var. mongolica
New high-field side magnetic probe array system for three-dimensional magnetic fluctuation measurements on EAST
期刊论文
OAI收割
FUSION ENGINEERING AND DESIGN, 2024, 卷号: 207
作者:
Lan, H.
;
Shi, T. H.
;
Yan, N.
;
Li, X. Q.
;
Li, S.
  |  
收藏
  |  
浏览/下载:13/0
  |  
提交时间:2024/11/20
EAST
HFS-MPA
Calibration
3D magnetic fluctuations
Mode propagation
AI-driven antibody design with generative diffusion models: current insights and future directions
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 10
作者:
He, Xin-heng
;
Li, Jun-rui
;
Xu, James
;
Shan, Hong
;
Shen, Shi-yi
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2024/11/05
antibodies
generative model
diffusion
de novo antibody design
CDR optimization
model evaluation