中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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西北高原生物研究... [152]
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Discovery of indole derivatives as STING degraders
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 294, 页码: 21
作者:
An, Yuxiang
;
Zhang, Yan
;
Luo, Xin
;
Lan, Yaohan
;
Geng, Meiyu
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Autoimmune diseases
Degrader
Inflammatory
PROTAC
STING
Synergistic enhancement of mechanical strength, friction coefficient and wear resistance of C/C-ZrC-HfC-SiC carbon-ceramic composites through matrix-interface modification
期刊论文
OAI收割
CERAMICS INTERNATIONAL, 2025, 卷号: 51, 期号: 20, 页码: 30772-30786
作者:
Li YD(李亚东)
;
Zhang, Zhaofu
;
Chang ZH(常正华)
;
Liu ZS(刘子尚)
;
Hu, Zheng
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/09/15
C/C-ZrC-HfC-SiC carbon-ceramic composites
Microstructure
Mechanical properties
Friction and wear
Synergistic enhancement
Green synthesis of 2-trifluoromethylquinoline skeletons
via
organocatalytic
N
-[(
α
-trifluoromethyl)vinyl]isatins CN bond activation
期刊论文
OAI收割
CHINESE CHEMICAL LETTERS, 2025, 卷号: 36, 期号: 7, 页码: 10
作者:
Ji, Cong-Bin
;
Xie, Ding-Xiong
;
Chen, Mei
;
Lan, Ye-Ying
;
Zhang, Bao-Hua
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2025/07/25
N-[(alpha-Trifluoromethyl)vinyl]isatins
Pfitzinger-type reaction
C-N bond cleavage
2-CF3-quinoline-4-carboxamide
2-CF3-quinoline-4-carboxylicester
Molecular recognition of two approved drugs Macimorelin and Anamorelin by the growth hormone secretagogue receptor
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 11
作者:
Wang, Ruo-lan
;
Sun, Jun
;
Liu, Heng
;
Guo, Shi-meng
;
Zhang, Yu
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/08/20
growth hormone secretagogue receptor
anamorelin
macimorelin
molecular recognition
PI3K-dependent GAB1/Erk phosphorylation renders head and neck squamous cell carcinoma sensitive to PI3Kα inhibitors
期刊论文
OAI收割
CELL DEATH & DISEASE, 2025, 卷号: 16, 期号: 1, 页码: 13
作者:
Zhang, Xu
;
Xu, Jiao
;
Wang, Xuan
;
Xu, Lan
;
Zhang, Xi
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/08/20
A born ultramassive white dwarf-hot subdwarf super-Chandrasekhar candidate
期刊论文
OAI收割
SCIENCE CHINA-PHYSICS MECHANICS & ASTRONOMY, 2025, 卷号: 68, 期号: 6
作者:
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2025/05/05
stars:horizontal branch
subdwarfs
binaries:close
white dwarfs
stars:neutron
supernovae:general
Structure-activity relationship analysis of meta-substituted N-cyclopropylmethyl-nornepenthones with mixed KOR/MOR activities
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 289, 页码: 15
作者:
Tang, Siyuan
;
Hu, Shuyang
;
Feng, Lijing
;
Kong, Linghui
;
Gui, Jiangwen
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/05/27
N-Cyclopropylmethyl-nornepenthones
Structure-activity relationship
MOR antagonist
KOR agonist
Substance use disorder
Screening and preparation of nanobodies for SIGLEC-15 detection
期刊论文
OAI收割
PROTEIN EXPRESSION AND PURIFICATION, 2025, 卷号: 229, 页码: 9
作者:
Zhao, Shuaiying
;
Li, Lingyun
;
Lan, Zhongyun
;
Hou, Xiangyun
;
Huang, Ruimin
  |  
收藏
  |  
浏览/下载:80/0
  |  
提交时间:2025/04/01
SIGLEC-15
Nanobody
Expression
Purification
Substrate recognition and cleavage mechanism of the monkeypox virus core protease
期刊论文
OAI收割
NATURE, 2025, 页码: 29
作者:
Gao, Yan
;
Xie, Xiong
;
Zhang, Xiaoyu
;
Cao, Junyuan
;
Lan, Weiqi
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/08/20
Targeting the histone reader ZMYND8 inhibits antiandrogen-induced neuroendocrine tumor transdifferentiation of prostate cancer
期刊论文
OAI收割
NATURE CANCER, 2025, 页码: 37
作者:
Wang, Hanling
;
Zhang, Sulin
;
Pan, Qiang
;
Guo, Jiacheng
;
Li, Ni
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/05/27