中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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Design, synthesis and bio-evaluation of 2,5-disubstituted thiazole derivatives for potential treatment of acute myeloid leukemia through targeting CDK9
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 160, 页码: 16
作者:
Chen, Sumeng
;
Huang, Jindi
;
Zhang, Shipeng
;
Zheng, Xinni
;
Chen, Hongming
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/06/23
CDK9
Inhibitor
Acute myeloid leukemia
Binding mode
Cellular mechanism
Effects of strain rate, temperature, and defects on mechanical properties of xgraphene: Molecular dynamics study
期刊论文
OAI收割
COMPUTATIONAL MATERIALS SCIENCE, 2025, 卷号: 254, 页码: 13
作者:
Peng Q(彭庆)
;
Li, Ao
;
Chen, Gen
;
Huang, Zeyu
;
Chen X(陈雪)
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/06/23
Xgraphene
Mechanical properties
Molecular dynamics
Defects
A Mitochondrion-Targeted NIR-II Modulator for Synergistic Ferroptosis-Immunotherapy
期刊论文
OAI收割
SMALL, 2025, 页码: 13
作者:
Wang, Miao
;
Ding, Qihang
;
Su, Wuyue
;
Luo, Min
;
Yang, Runping
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/06/23
antitumor immunity activity
ferroptosis
immunogenic cell death
mitochondria targeting
NIR-II modulator
Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression
期刊论文
OAI收割
CANCER RESEARCH, 2025, 卷号: 85, 期号: 7, 页码: 1253-1269
作者:
Chen, Ran
;
Ma, Cuihong
;
Qian, Haoran
;
Xie, Xinyu
;
Zhang, Yuxue
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2025/05/27
Discovery of a novel polymyxin adjuvant against multidrug-resistant gram-negative bacteria through oxidative stress modulation
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1680-1695
作者:
Lu, Taotao
;
Han, Hongguang
;
Wu, Chaohui
;
Li, Qian
;
Hu, Hongyan
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/06/23
Multidrug resistance
Gram-negative bacteria
Niclosamide
Drug repurposing
Polymyxin B
Adjuvant
Broad-spectrum synergism
Oxidative stress
CXCR2 modulates chronic pain comorbid depression in mice by regulating adult neurogenesis in the ventral dentate gyrus
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13
作者:
Li, Xiao-jie
;
Wu, Shuo
;
Liu, Zi-han
;
Liu, An-an
;
Peng, Hui-sheng
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/04/01
chronic pain comorbid depression
adult neurogenesis
dentate gyrus
CXCR2
Wnt3a/beta-catenin pathway
IHCH9033, a novel class I HDAC inhibitor, synergizes with FLT3 inhibitor and rescues quizartinib resistance in FLT3-ITD AML via enhancing DNA damage response
期刊论文
OAI收割
EXPERIMENTAL HEMATOLOGY & ONCOLOGY, 2025, 卷号: 14, 期号: 1, 页码: 19
作者:
Yao, Mingyue
;
Yan, Wenzhong
;
Wang, Yafang
;
Zhao, Yu
;
Xu, Xiaowei
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/04/01
Acute myeloid leukemia
HDAC inhibitor
FLT3-ITD mutation
DNA damage response
Synergistic effect
Drug resistance
Concurrent inhibition of p300/CBP and FLT3 enhances cytotoxicity and overcomes resistance in acute myeloid leukemia
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 14
作者:
Chen, Yu-jun
;
Zhao, Yu
;
Yao, Ming-yue
;
Wang, Ya-fang
;
Ma, Ming
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/04/01
acute myeloid leukemia
FLT3
p300/CBP
quizartinib resistance
combination strategy
Geometrical Distances of Extragalactic Binaries through Spectroastrometry
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 979, 期号: 1, 页码: 13
作者:
Songsheng, Yu-Yang
;
Wang, Jian-Min
;
Cao, Yuan
;
Chen XF(陈雪飞)
;
Xiong JP(熊建萍)
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2025/02/24
Inhibited peroxidase activity of peroxiredoxin 1 by palmitic acid exacerbates nonalcoholic steatohepatitis in male mice
期刊论文
OAI收割
NATURE COMMUNICATIONS, 2025, 卷号: 16, 期号: 1, 页码: 19
作者:
Yin, Wen
;
Xu, Heng
;
Bai, Zhonghao
;
Wu, Yue
;
Zhang, Yan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/04/01