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A nanobody-enzyme fusion protein targeting PD-L1 and sialic acid exerts anti-tumor effects by C-type lectin pathway-mediated tumor associated macrophages repolarizing
期刊论文
OAI收割
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2025, 卷号: 298, 页码: 13
作者:
Tong, Yongliang
;
Chen, Runqiu
;
Lu, Xinrong
;
Chen, Cuiying
;
Sun, Guiqin
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/04/01
Glycol-immunology
Nanobody-enzyme fusion protein
Sialic acid
Design, Synthesis, and Pharmacological Evaluation of Quinazoline and Quinoline Derivatives as Potent ENPP1 Inhibitors for Cancer Immunotherapy
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 18
作者:
He, Jie
;
Ma, Xiaoyu
;
Sun, Jia
;
Chen, Manman
;
Xu, Lan
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2025/04/01
A novel cocrystal of indole-3-propionic acid and nicotinamide: Structure design, preparation, characterization and preliminary physiochemical properties evaluation
期刊论文
OAI收割
JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1322, 页码: 9
作者:
Guo, Jiacheng
;
Xu, Lingling
;
You, Wen
;
Ji, Yuze
;
Chen, Dongying
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/12/25
Indole-3-propionic acid
Nicotinamide
Cocrystal
Solubility
Permeability
Stability
Molecular Imaging of Ovarian Follicles and Tumors With Near-Infrared II Bioconjugates
期刊论文
OAI收割
ADVANCED MATERIALS, 2024, 页码: 13
作者:
Wang, Yicong
;
Lu, Wenhan
;
Chen, Zi-Han
;
Xiao, Yan
;
Wang, Yu
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/02/28
biomaterials
follicular tracking
multi-color imaging
near-infrared II bioconjugates
near-infrared II in vivo imaging
Chemical and biosynthetic potential of Penicillium shentong XL-F41
期刊论文
OAI收割
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 20, 页码: 597-606
作者:
Zou, Ran
;
Li, Xin
;
Chen, Xiaochen
;
Guo, Yue-Wei
;
Xu, Baofu
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/05/07
genome analysis
indole terpene alkaloid
natural products
Penicillium
structure elucidation
The enzyme activity of sortase A is regulated by phosphorylation in Staphylococcus aureus
期刊论文
OAI收割
VIRULENCE, 2023, 卷号: 14, 期号: 1, 页码: 2171641
作者:
Chen, Feifei
;
Di, Hongxia
;
Wang, Yanhui
;
Peng, Chao
;
Chen, Rongrong
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2024/03/27
Staphylococcus aureus
Sortase A
protein phosphorylation
virulence
Discovery of novel triazine derivatives as potent retinoic acid receptor-related orphan receptor gamma t (ROR gamma t) inverse agonists
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 256, 页码: 18
作者:
Lu, Lixue
;
Chen, Song
;
Yu, Mingcheng
;
Zhou, Ronghui
;
Guo, Siqi
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2023/10/17
ROR gamma t
Triazines
Inverse agonist
Psoriasis
Autoimmune diseases
Effect of an Herbal-Based Injection on 28-Day Mortality in Patients With Sepsis The EXIT-SEP Randomized Clinical Trial
期刊论文
OAI收割
JAMA INTERNAL MEDICINE, 2023, 卷号: 183, 期号: 7, 页码: 647-655
作者:
Liu, Songqiao
;
Yao, Chen
;
Xie, Jianfeng
;
Liu, Hong
;
Wang, Hongliang
  |  
收藏
  |  
浏览/下载:29/0
  |  
提交时间:2024/03/27
Recent advances of activation techniques-based discovery of new compounds from marine fungi
期刊论文
OAI收割
FITOTERAPIA, 2023, 卷号: 167, 页码: 14
作者:
Zou, Ran
;
Chen, Bao
;
Sun, Jie
;
Guo, Yue-Wei
;
Xu, Baofu
  |  
收藏
  |  
浏览/下载:20/0
  |  
提交时间:2023/10/17
Marine fungi
Silent
Biosynthetic gene clusters
Activation techniques
Optimization of carbazole carboxamide RORγt agonists: Challenges in improving the metabolic stability and maintaining the agonistic activity
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 251, 页码: 115213
作者:
Sun, Nannan
;
Yu, Mingcheng
;
Jiang, Zhengyuan
;
Yang, Feng
;
Lu, Lixue
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2024/03/27
ROR?t agonists
Carbazole carboxamide
Agonistic activity
Metabolic stability
Co-crystallization
Molecular docking