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Chinese Academy of Sciences Institutional Repositories Grid
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Conformational restriction enables discovering a series of chroman derivatives as potent and selective NaV1.8 inhibitors with improved pharmacokinetic properties
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 293, 页码: 24
作者:
Li, Na
;
Wang, Linlin
;
Hu, Xinyuan
;
Xu, Haiyan
;
Yang, Bowen
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/08/20
Voltage-gated sodium channel 1.8
Conformational restriction
Pharmacokinetic
Structure-activity relationship
Analgesic
Climate Variability and Agricultural Inputs: Effects on Grain Production and Yield Stability in China (1991-2020)
期刊论文
OAI收割
FOOD AND ENERGY SECURITY, 2025, 卷号: 14, 期号: 3, 页码: e70096
作者:
Gao, Runzhao
;
Cai, Hongyan
;
Xu, Xinliang
  |  
收藏
  |  
浏览/下载:7/0
  |  
提交时间:2025/07/18
agricultural inputs
climate variability
grain production stability
grain yield stability
interaction effects
Broadband γ-Ray Spectrum of Supernova Remnant Cassiopeia A
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 982, 期号: 1
作者:
Cao, Zhen
;
Aharonian, F.
;
Bai, Y. X.
;
Bao, Y. W.
;
Bastieri, D.
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2025/05/05
Constraining the Cosmic-Ray Energy Based on Observations of Nearby Galaxy Clusters by LHAASO
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 982, 期号: 1
作者:
  |  
收藏
  |  
浏览/下载:87/0
  |  
提交时间:2025/05/05
Discovery of Covalent and Cell-Active ALKBH5 Inhibitors with Potent Antileukemia Effects
In Vivo
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 9
作者:
Wu, Hengbo
;
Lai, Gan-Qiang
;
Cheng, Ruixiang
;
Huang, Hui
;
Wang, Ju
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/04/24
RNA epigenetics
N
(6)-methyladenosine
ALKBH5
covalent inhibitor
antileukemia
Terrestrial ecosystem response to Early Cretaceous global environmental change: A calibrated, high-resolution Aptian record from Northeast China
期刊论文
OAI收割
EARTH AND PLANETARY SCIENCE LETTERS, 2025, 卷号: 653, 页码: 13
作者:
Sun, Ming-Dao
;
Lin, Qin
;
Ramezani, Jahandar
;
Liu, Jiang-Si
;
Lu, Zheng-An
  |  
收藏
  |  
浏览/下载:52/0
  |  
提交时间:2025/04/03
Early Cretaceous
Aptian
CA-ID-TIMS geochronology
Astrochronology
Carbon isotope stratigraphy
Soft X-ray prompt emission from the high-redshift gamma-ray burst EP240315a
期刊论文
OAI收割
NATURE ASTRONOMY, 2025, 页码: 14
作者:
Liu, Y.
;
Sun, H.
;
Xu, D.
;
Svinkin, D. S.
;
Delaunay, J.
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/04/17
Discovery of Novel RNA Demethylase FTO Inhibitors Featuring an Acylhydrazone Scaffold with Potent Antileukemia Activity
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 22
作者:
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2025/04/01
De Novo siRNA nanoplatform with NIR-II imaging for treatment of carotid atherosclerotic plaques
期刊论文
OAI收割
CHEMICAL ENGINEERING JOURNAL, 2025, 卷号: 503, 页码: 13
作者:
Gao, Jialu
;
Zhu, Hua
;
Cai, Huanhuan
;
Ding, Qihang
;
Xiong, Xiaoxing
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/02/28
siRNA delivery
Atheromatous plaques
NIR-II imaging
Multifunctional nanoplatform
Epsin1/2
Microstructural and Seismic Characteristics of Mantle Xenoliths From Damaping Area, and Their Geodynamic Implications of North China Craton Destruction
期刊论文
OAI收割
TECTONICS, 2025, 卷号: 44, 期号: 1, 页码: 24
作者:
Shao, Yilun
;
Liu, Cai
;
Gao, Rui
;
Li, Shan
;
Zhao, Tianshuo
  |  
收藏
  |  
浏览/下载:16/0
  |  
提交时间:2025/04/01
damaping mantle xenoliths
CPO
transpression
seismic anisotropy
asthenosphere circulation