中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
机构
上海药物研究所 [19]
化学研究所 [8]
重庆绿色智能技术研究... [5]
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期刊论文 [78]
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Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:
Tang, Cai-ling
;
Li, Yuan-qing
;
Du, Xi-kun
;
Fang, Xiao-xia
;
Guang, Yi-man
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/04/01
dynamics simulation
CECR2
covalent inhibitor
allosteric effect
FAPM: functional annotation of proteins using multimodal models beyond structural modeling
期刊论文
OAI收割
BIOINFORMATICS, 2024, 卷号: 40, 期号: 12, 页码: 12
作者:
Xiang, Wenkai
;
Xiong, Zhaoping
;
Chen, Huan
;
Xiong, Jiacheng
;
Zhang, Wei
  |  
收藏
  |  
浏览/下载:94/0
  |  
提交时间:2025/01/14
Design, synthesis, and biological evaluation of pyrido[2,3-d]pyrimidin-7 (8H)-one derivatives as potent USP1 inhibitors
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 275, 页码: 18
作者:
Li, Hongrui
;
Liu, Ben-Jin
;
Xu, Jiahao
;
Song, Shan-Shan
;
Ba, Ruixian
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/08/22
USP1 inhibitor
Structure -activity relationships
Olaparib-resistant cell
Rethinking Polyp Segmentation from An Out-of distribution Perspective
期刊论文
OAI收割
Machine Intelligence Research, 2024, 卷号: 21, 期号: 4, 页码: 631-639
作者:
Ge-Peng Ji
;
Jing Zhang
;
Dylan Campbell
;
Huan Xiong
;
Nick Barnes
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2024/07/18
Polyp segmentation
anomaly segmentation
out-of-distribution segmentation
masked autoencoder
abdomen
E3 ligase ligand optimization of Clinical PROTACs
期刊论文
OAI收割
FRONTIERS IN CHEMISTRY, 2023, 卷号: 11, 页码: 15
作者:
Jiang, Hanrui
;
Xiong, Huan
;
Gu, Shuang-Xi
;
Wang, Mingliang
  |  
收藏
  |  
浏览/下载:22/0
  |  
提交时间:2023/04/10
PROTACs
E3 ubiquitin ligase ligand
structure optimization
clinical trials
CRBN
Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 24, 页码: 16526-16540
作者:
Xie, Xiong
;
Zheng, Yu-Gui
;
Chen, Huan
;
Li, Jian
;
Luo, Rong-Hua
  |  
收藏
  |  
浏览/下载:34/0
  |  
提交时间:2023/04/10
Exploring the impact of mass migration in Jin Dynasty by psycholinguistic analysis on Classical Chinese legacy text
期刊论文
OAI收割
FRONTIERS IN PSYCHOLOGY, 2022, 卷号: 13, 页码: 8
作者:
Xiong, Huan
;
Wu, Gengxuan
;
Li, Sijia
;
Xue, Shujie
;
Li, Hua
  |  
收藏
  |  
浏览/下载:35/0
  |  
提交时间:2023/01/06
psycholinguistic analysis
word frequency analysis
LIWC
Classical Chinese legacy text
mass migration
gentry of the Jin Dynasty
Entrenchment of the Yellow River since the late Miocene under changing tectonics and climate
期刊论文
OAI收割
GEOMORPHOLOGY, 2022, 卷号: 416, 页码: 28
作者:
Xiong, Jianguo
;
Liu, Yunming
  |  
收藏
  |  
浏览/下载:26/0
  |  
提交时间:2023/04/06
Yellow River
Jinshaan Gorge
Magnetostratigraphy
Zircon U-Pb chronology
Tectonic and climatic impacts
Northeastern Tibetan Plateau
The effect and mechanism of traditional Chinese exercise for chronic low back pain in middle-aged and elderly patients: A systematic review
期刊论文
OAI收割
FRONTIERS IN AGING NEUROSCIENCE, 2022, 卷号: 14, 页码: 10
作者:
Wang, Xue-Qiang
;
Xiong, Huan-Yu
;
Du, Shu-Hao
;
Yang, Qi-Hao
;
Hu, Li
  |  
收藏
  |  
浏览/下载:30/0
  |  
提交时间:2022/11/19
chronic low back pain
traditional Chinese exercise
elderly people
Tai Chi
Qigong
SOMCL-19-133, a novel, selective, and orally available inhibitor of NEDD8-activating enzyme (NAE) for cancer therapy
期刊论文
OAI收割
NEOPLASIA, 2022, 卷号: 32, 页码: 12
作者:
Zhou, Li-Na
;
Xiong, Chaodong
;
Cheng, Yong-Jun
;
Song, Shan-Shan
;
Bao, Xu-Bin
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2023/04/10
SOMCL-19-133
NAE inhibitor
MLN4924
NEDD8
Oral administration