中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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近代物理研究所 [43]
上海药物研究所 [36]
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期刊论文 [388]
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Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Spectroastrometry and Reverberation Mapping of Active Galactic Nuclei. II. Measuring Geometric Distances and Black Hole Masses of Four Nearby Quasars
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL, 2025, 卷号: 988, 期号: 1
作者:
Li, Yan-Rong
;
Shangguan, Jinyi
;
Wang, Jian-Min
;
Davies, Ric
;
Santos, Daryl J. D.
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2025/07/21
Characterization of endogenous SUMOylation sites by click chemistry-based proteomics
期刊论文
OAI收割
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2025, 页码: 15
作者:
Ma, Ke
;
Chen, Sixian
;
Zhang, Jun
;
Jia, Xinglong
;
Fan, Rufeng
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/08/20
SUMOylation
Click chemistry
Proteomics
Post-translational modification
Cross-Linking Profiling of Molecular Glue Degrader-Induced E3 Ligase Interactome to Expand Target Space
期刊论文
OAI收割
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 13
作者:
Xu, Yali
;
Zhao, Wensi
;
Nie, Hui-Jun
;
Wang, Jiamin
;
Fu, Jingjing
  |  
收藏
  |  
浏览/下载:25/0
  |  
提交时间:2025/05/27
Chemoproteomics
Genetic code expansion
Molecular glue degrader
Photo-crosslinking
Targeted protein degradation
Benzofurans and dibenzofurans from galls on twigs of the endangered Chinese endemic tree
Parrotia
subaequalis
and their inhibitory properties against
Staphylococcus
aureus
and ATP-citrate lyase
期刊论文
OAI收割
PHYTOCHEMISTRY, 2025, 卷号: 229, 页码: 9
作者:
Zhou, Peng-Jun
;
Wu, Xi-Ying
;
Zhao, Ze-Yu
;
Zang, Yi
;
Sun, Zhong-Shuai
  |  
收藏
  |  
浏览/下载:47/0
  |  
提交时间:2024/11/26
Parrotia subaequalis
Hamamelidaceae
Gall
Phytoalexins
Benzofuran
Dibenzofuran
Staphylococcus aureus
ATP-Citrate lyase
Structure-guided design and photochemical synthesis of new carbamo (dithioperoxo)thioates with improved potencies to SARS-CoV-2 3CLpro
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2024, 卷号: 114, 页码: 9
作者:
Yin, De-Hang
;
Xin, Jie
;
Chen, Shizhao
;
Li, Shuai-Shuai
;
Li, Zi-Ying
  |  
收藏
  |  
浏览/下载:38/0
  |  
提交时间:2024/12/11
SARS-CoV-2
Disulfiram
Carbamo(dithioperoxo)thioates
Photochemistry
3CL pro
Mass balance, metabolism, and pharmacokinetics of [
14
C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers
期刊论文
OAI收割
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:
Zhao, Chun-Yang
  |  
收藏
  |  
浏览/下载:28/0
  |  
提交时间:2025/01/06
amdizalisib
PI3K delta kinase
metabolism
mass balance
metabolite identification
pharmacokinetics
safety
Phytochemical and biological studies on rare and endangered plants endemic to China. Part XXXVI. Tsugaforrestiacids A - O: Structurally diverse C-18 carboxylated diterpenoids from the twigs and needles of the 'vulnerable ' conifer Tsuga forrestii and their inhibitory effects on ATP-citrate lyase
期刊论文
OAI收割
PHYTOCHEMISTRY, 2024, 卷号: 226, 页码: 13
作者:
Zhou, Peng -Jun
;
Zhao, Ze-Yu
;
Zhu, Jin-Xin
;
Zang, Yi
;
Benjamin, Menny M.
  |  
收藏
  |  
浏览/下载:18/0
  |  
提交时间:2024/08/22
Tsuga forrestii
Pinaceae
Rare and endangered plants (REPs)
Diterpenoid acids
ATP citrate lyase (ACL)
Molecular docking
Chemotaxonomy
Tofacitinib prevents depressive-like behaviors through decreased hippocampal microgliosis and increased BDNF levels in both LPS-induced and CSDS-induced mice
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Gao, Ya-nan
;
Pan, Kai-jun
;
Zhang, Yong-mei
;
Qi, Ying-bei
;
Chen, Wen-gang
  |  
收藏
  |  
浏览/下载:32/0
  |  
提交时间:2024/11/05
tofacitinib
depression
JAK-STAT pathway
microgliosis
synaptic defects
Dual-comb spectroscopy over a 100 km open-air path
期刊论文
OAI收割
NATURE PHOTONICS, 2024, 卷号: 18, 期号: 11, 页码: 1195–1202
作者:
Han, Jin-Jian
;
Zhong, Wei
;
Zhao, Ruo-Can
;
Zeng, Ting
;
Li, Min
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2024/11/27