中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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上海药物研究所 [104]
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期刊论文 [864]
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Plant Sci... [17]
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Discovery of novel imidazo[2,1-b][1,3,4]thiadiazole analogs as fluorescent SHP2 inhibitors
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2025, 卷号: 163, 页码: 10
作者:
Zhang, Chun
;
Yan, Xue
;
Gao, Li-Xin
;
Cao, Zi-Tong
;
Cao, Qing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/08/20
Imidazo[2,1-b][1,3,4]thiadiazole
Inhibitory activities
Fluorescence imaging
Zebrafish
SHP2
Guiding precision medicine strategy for intravenous ginsenosides via pharmacokinetic-informed bioinformatic approaches: a study on XueShuanTong
期刊论文
OAI收割
PHYTOMEDICINE, 2025, 卷号: 143, 页码: 18
作者:
Jia, Wei-Wei
;
Tian, Nan-Nan
;
Song, Zi-Jing
;
Lan, Xiao-Fang
;
Yang, Xi-He
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Precision medicine
Physiologically based pharmacokinetic model
Ginsenoside
Albumin-facilitated dissociation
Drug interaction
Drug transporter
Hepatic impairment
Nonlinear Imaging Detection of Organ Fibrosis in Minute Samples for Early Stage Utilizing Dual-Channel Two-Photon and Second-Harmonic Excitation
期刊论文
OAI收割
BIOSENSORS-BASEL, 2025, 卷号: 15, 期号: 6, 页码: 16
作者:
Yu, Bo-Song
;
Cheng, Qing-Di
;
Liu, Yi-Zhou
;
Zhang, Rui
;
Li, Da-Wei
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
nonlinear imaging
two-photon excitation
second harmonic generation
fibrosis
Glabridin as a selective Kv2.1 inhibitor ameliorates DPN pathology by disrupting the Aβ/Kv2.1/JNK/NF-κB/NLRP3/p-Tau pathway
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 17
作者:
Xu, Jia-wen
;
Ma, Lin
;
Xiang, Yu
;
Dai, Meng-qing
;
Li, Qiu-hui
  |  
收藏
  |  
浏览/下载:19/0
  |  
提交时间:2025/05/27
diabetic peripheral neuropathy
glabridin
Kv2.1
dorsal root ganglia
Schwann cells
A beta/Kv2.1/NLRP3/p-Tau axis
Microplastic-Induced Alterations in Soil Aggregate-Associated Carbon Stabilization Pathways: Evidence from δ13C Signature Analysis
期刊论文
OAI收割
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2025, 卷号: 59, 期号: 11, 页码: 5545-5555
作者:
Li, Yanpei
;
Yan, Qing
;
Zou, Chuningrui
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2025/04/21
microplastics
soil aggregate
delta C-13 signature
aggregate-associated organic carbon
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:
Tang, Cai-ling
;
Li, Yuan-qing
;
Du, Xi-kun
;
Fang, Xiao-xia
;
Guang, Yi-man
  |  
收藏
  |  
浏览/下载:33/0
  |  
提交时间:2025/04/01
dynamics simulation
CECR2
covalent inhibitor
allosteric effect
π-HuB: the proteomic navigator of the human body
期刊论文
OAI收割
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
作者:
He, Fuchu
;
Aebersold, Ruedi
;
Baker, Mark S.
;
Bian, Xiuwu
;
Bo, Xiaochen
  |  
收藏
  |  
浏览/下载:43/0
  |  
提交时间:2025/04/01
Ultra-Efficient and Cost-Effective Platinum Nanomembrane Electrocatalyst for Sustainable Hydrogen Production
期刊论文
OAI收割
NANO-MICRO LETTERS, 2024, 卷号: 16, 期号: 1, 页码: 16
作者:
Gao, Xiang
;
Dai, Shicheng
;
Teng, Yun
;
Wang, Qing
;
Zhang, Zhibo
  |  
收藏
  |  
浏览/下载:58/0
  |  
提交时间:2024/03/11
Platinum
Hydrogen evolution reaction
Lattice distortion
Heterogeneous strain
An automatic LC-MS/MS data analysis workflow for herbal compound annotation with AutoAnnotatoR: A case study of ten botanical origins of Fritillaria species
期刊论文
OAI收割
PHYTOMEDICINE, 2024, 卷号: 135, 页码: 12
作者:
An, Ya-ling
;
Li, Jia-yuan
;
Wei, Wen-long
;
Li, Yun
;
Zhang, Jian-qing
  |  
收藏
  |  
浏览/下载:27/0
  |  
提交时间:2024/12/11
Botanical natural products
Automatic compound annotation
LC-MS/MS
AutoAnnotatoR
Comprehensive multi-omics analysis elucidates colchicine-induced toxicity mechanisms and unveils the therapeutic potential of MLN4924 and kinase inhibitors
期刊论文
OAI收割
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 13
作者:
Zhai, Lin-hui
;
Jia, Xing-long
;
Chen, Yu-lu
;
Liu, Mu-yin
;
Zhang, Jing-dan
  |  
收藏
  |  
浏览/下载:95/0
  |  
提交时间:2024/12/25
colchicine
MLN4924
multi-omics analysis
phosphoproteomics
ubiquitinomics
kinase inhibitor