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Pharmacokinetics, mass balance, and metabolism of [
14
C]PLB1004, a selective and irreversible EGFR-TKI in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 14
作者:
Liu, Donghui
;
Li, Qian
;
Yan, Shu
;
Zhang, Xinyue
;
Li, Weiqiang
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2025/04/01
PLB1004
[C-14]PLB1004
Radioactivity
Mass balance
EGFR-TKI
Qualitative and quantitative determination of SIPI-2011 and its two major metabolites in human plasma
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 卷号: 264, 页码: 11
作者:
Fang, Jie
;
Jing, Jiao
;
Li, Guangyao
;
Wang, Yongbin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
SIPI-2011
UPLC-UV/Q-TOF
LC-MS/MS
Metabolic Profiling
Pharmacokinetics
Multi-parameter optimisation of optical bonding for the ultra-stable optical measurement bench in space-based platform
期刊论文
OAI收割
OPTICS AND LASER TECHNOLOGY, 2025, 卷号: 188, 页码: 14
作者:
Pan, Guotao
;
Deng, Xiaoqin
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/06/23
Space-based platform
Optical bonding technology
Multi-parameter
Ultra-stable optical measurement bench
Noise stability measurement
Design, synthesis and structure-activity relationship studies of novel macrocyclic 2,4-diaminopyrimidines as HPK1 inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 12
作者:
Wu, Feifei
;
Sun, Jiaqi
;
Xu, Mingyang
;
Li, Huiyu
;
Wei, Jiarui
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
Macrocycle
Kinase
Inhibitors
HPK1
Cancer immunotherapy
Design, synthesis, and biological evaluation of thioamide-linked spiropyrrolidine derivatives as novel 3CL
pro
inhibitors against SARS-CoV-2
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 128, 页码: 11
作者:
Guma, Samuel Desta
;
Song, Kang
;
Sun, Haiguo
;
Yang, Lei
;
Zhou, Zhaoyin
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20
SARS-CoV-2
3CL(pro) inhibitors
Thioamide derivatives
Spiropyrrolidine derivatives
Nirmatrelvir
HCoV-OC43
Antiviral
Metabolic stability
EP240801a/XRF 240801B: An X-Ray Flash Detected by the Einstein Probe and the Implications of Its Multiband Afterglow
期刊论文
OAI收割
ASTROPHYSICAL JOURNAL LETTERS, 2025, 卷号: 988, 期号: 1
作者:
Jiang, Shuai-Qing
;
Xu, Dong
;
Hoof, Agnes P. C. van
;
Lei, Wei-Hua
;
Liu, Yuan
  |  
收藏
  |  
浏览/下载:21/0
  |  
提交时间:2025/07/28
First polarization study of the M87 jet and active galactic nuclei at submillimeter wavelengths with ALMA
期刊论文
OAI收割
ASTRONOMY & ASTROPHYSICS, 2025, 卷号: 699
作者:
Goddi, Ciriaco
;
Carlos, Douglas F.
;
Crew, Geoffrey B.
;
Matthews, Lynn D.
;
Messias, Hugo
  |  
收藏
  |  
浏览/下载:9/0
  |  
提交时间:2025/08/25
black hole physics
magnetic fields
polarization
radiation mechanisms: non-thermal
instrumentation: interferometers
instrumentation: polarimeters
The Overview and Trial Observations of AIMS
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 7
作者:
Deng, Yuanyong
;
Wang, Dongguang
;
Hua, Jianwen
;
Xu, Songbo
;
Liang, Ming
  |  
收藏
  |  
浏览/下载:23/0
  |  
提交时间:2025/07/14
Sun: infrared
methods: observational
instrumentation: spectrographs
Discussion of "Volume Contraction and Reduction in Hydraulic Conductivity during Particle Crushing"
期刊论文
OAI收割
JOURNAL OF GEOTECHNICAL AND GEOENVIRONMENTAL ENGINEERING, 2025, 卷号: 151, 期号: 6, 页码: 3
作者:
Liu, Xinyu
;
Zhang, Xianwei
;
Yan, Lei
;
Wei, Gang
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/06/27
Osteoarthritis treatment via the GLP-1-mediated gut-joint axis targets intestinal FXR signaling
期刊论文
OAI收割
SCIENCE, 2025, 卷号: 388, 期号: 6742, 页码: 13
作者:
Yang, Yuanheng
;
Hao, Cong
;
Jiao, Tingying
;
Yang, Zidan
;
Li, Hui
  |  
收藏
  |  
浏览/下载:1/0
  |  
提交时间:2025/08/20