中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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CAS IR Grid
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上海药物研究所 [45]
金属研究所 [27]
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期刊论文 [249]
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Pharmacokinetics, mass balance, and metabolism of [
14
C]PLB1004, a selective and irreversible EGFR-TKI in humans
期刊论文
OAI收割
CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2025, 卷号: 95, 期号: 1, 页码: 14
作者:
Liu, Donghui
;
Li, Qian
;
Yan, Shu
;
Zhang, Xinyue
;
Li, Weiqiang
  |  
收藏
  |  
浏览/下载:10/0
  |  
提交时间:2025/04/01
PLB1004
[C-14]PLB1004
Radioactivity
Mass balance
EGFR-TKI
Quantification of serum daratumumab in multiple myeloma patients by LC-MS/MS, comparison with ELISA
期刊论文
OAI收割
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2025, 卷号: 255, 页码: 7
作者:
Li, Weiqiang
;
Tian, Zhuoran
;
Yu, Xiong
;
Xu, Hongyu
;
Huang, Fang
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/02/28
Multiple myeloma
Daratumumab
LC-MS/MS
Surrogate peptide
Design, Synthesis, and biological evaluation of 7H-Pyrrolo[2,3-d] pyrimidines as potent HPK1 kinase inhibitors
期刊论文
OAI收割
BIOORGANIC & MEDICINAL CHEMISTRY, 2025, 卷号: 119, 页码: 13
作者:
Wu, Feifei
;
Li, Huiyu
;
Li, Weiqiang
;
Zhang, Laishun
;
An, Qi
  |  
收藏
  |  
浏览/下载:4/0
  |  
提交时间:2025/04/01
Optimization
Hematopoietic progenitor kinase 1
Inhibitor
Cancer immunotherapy
Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel
Hs
ClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307
作者:
Sun, Mingyang
;
Chen, Beijing
;
Teng, Dan
;
Zhao, Hongshen
;
Liao, Yilie
  |  
收藏
  |  
浏览/下载:11/0
  |  
提交时间:2025/04/01
PEGylation of Dipeptide Linker Improves Therapeutic Index and Pharmacokinetics of Antibody-Drug Conjugates
期刊论文
OAI收割
BIOCONJUGATE CHEMISTRY, 2025, 页码: 11
作者:
Long, Jing
;
Shao, Ting
;
Wang, Yongmei
;
Chen, Tianzhi
;
Chen, Yuning
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/04/01
Simultaneous Quantification of Total Antibody and Conjugated Payload for DS001 in Rat Serum Using a Hybrid Immuno-Capture LC-MS/MS
期刊论文
OAI收割
AAPS JOURNAL, 2025, 卷号: 27, 期号: 1, 页码: 13
作者:
Yu, Xiong
;
Li, Weiqiang
;
Huang, Wensi
;
Xiao, Bo
;
Long, Jing
  |  
收藏
  |  
浏览/下载:5/0
  |  
提交时间:2025/04/01
ADC
LC-MS/MS
payload
simultaneous quantification
total antibody
Utility of quantitative whole-body autoradiography (QWBA) and oxidative combustion (OC) analysis in the assessment of tissue distribution of [
14
C]Mefuparib (CVL218) in SD and LE rats
期刊论文
OAI收割
PLOS ONE, 2024, 卷号: 19, 期号: 12, 页码: 13
作者:
Li, Xinmei
;
Wang, Feiyu
;
Zhang, Xinyue
;
Shen, Xiaokun
;
Yang, Chunhao
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/04/01
Discovery of a Potent, selective and orally bioavailable CDK9 degrader for targeting transcription regulation in Triple-Negative breast cancer
期刊论文
OAI收割
BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 16
作者:
Nie, Hui-Jun
;
Li, Ben-Fu
;
Sun, Jingya
;
Yuan, Yali
;
Zhang, Zhi-Gao
  |  
收藏
  |  
浏览/下载:8/0
  |  
提交时间:2024/11/26
Triple-negative breast cancer
Targeting transcription regulation
Orally bioavailable degrader
PROTAC
Cyclin-dependent Kinase 9
Taxonomic composition and functional potentials of gastrointestinal microbiota in 12 wild-stranded cetaceans
期刊论文
OAI收割
FRONTIERS IN MICROBIOLOGY, 2024, 卷号: 15, 页码: 14
作者:
Fan, Jie
;
Kang, Hui
;
Lv, Meiqi
;
Zhai, Yuhuan
;
Jia, Yangyang
  |  
收藏
  |  
浏览/下载:12/0
  |  
提交时间:2024/10/21
stranded cetaceans
delphinids
physeteroids and ziphiid
gut microbiota
gastrointestinal microbiota
functional potentials
food digestion
Discovery of Orally Bioavailable and Potent CDK9 Inhibitors for Targeting Transcription Regulation in Triple-Negative Breast Cancer
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 12, 页码: 10035-10056
作者:
Wang, Wen-Jing
;
Gao, Lixin
;
Wang, Simei
;
Huang, Wensi
;
Meng, Xin-Yu
  |  
收藏
  |  
浏览/下载:6/0
  |  
提交时间:2024/08/20