中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
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金属研究所 [34]
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期刊论文 [227]
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Discovery and optimization of Menin-MLL inhibitors targeting acute myeloid leukemia
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2026, 卷号: 307, 页码: 15
作者:
Xiao, Qitao
;
Wang, Yuxian
;
Shen, Zheyuan
;
Mo, Jun
;
Li, Cong
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/04/01
MLL-R AML
Menin inhibitor
thieno[2
d ]pyrimidine
Machine learning
Rational engineering of degradation tail-driven CELMoD-antibody conjugates for precision malignancy therapy
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 12, 页码: 6510-6528
作者:
Guo, Yu
;
Song, Yi
;
Wang, Hanlin
;
Lu, Yang
;
Zhang, Jingyu
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2026/01/29
Degrader-antibody conjugate
Antibody-drug conjugate
Cereblon E3 ligase modulator
Immunomodulatory drug
Molecular glue
Targeted protein degradation
Multiple myeloma
Hematologic malignancy
Modular PROTAC/IMiD Bifunctional Molecule Design for the Degradation of Synergistic Targets in the Treatment of Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 20, 页码: 21249-21281
作者:
Jin, Yuheng
;
Liao, Xueyan
;
Zhang, Jingyu
;
Duan, Haiting
;
Xu, Ran
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
Design, synthesis, and evaluation of Menin-targeting compounds for the treatment of acute Myelocytic leukemia (AML)
期刊论文
OAI收割
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 296, 页码: 17
作者:
Mo, Jun
;
Wang, Yuxian
;
Pan, Youlu
;
Xiao, Qitao
;
Zhao, Jinyi
  |  
收藏
  |  
浏览/下载:37/0
  |  
提交时间:2025/08/20
Menin
High binding affinity
Anti-proliferation activity
AML
Discovery of a Selective and Potent BCL6 PROTAC with Efficacious Antiproliferative Activity for the Treatment of Diffuse Large B-Cell Lymphoma
期刊论文
OAI收割
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 19, 页码: 20180-20206
作者:
Yu, Xiaoli
;
Liao, Xueyan
;
Zhang, Jingyu
;
Wang, Hanlin
;
Li, Xian
  |  
收藏
  |  
浏览/下载:0/0
  |  
提交时间:2025/12/04
The Overview and Trial Observations of AIMS
期刊论文
OAI收割
RESEARCH IN ASTRONOMY AND ASTROPHYSICS, 2025, 卷号: 25, 期号: 7
作者:
Deng, Yuanyong
;
Wang, Dongguang
;
Hua, Jianwen
;
Xu, Songbo
;
Liang, Ming
  |  
收藏
  |  
浏览/下载:71/0
  |  
提交时间:2025/07/14
Sun: infrared
methods: observational
instrumentation: spectrographs
Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function
期刊论文
OAI收割
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679
作者:
Jin, Yuheng
;
Qi, Xuxin
;
Yu, Xiaoli
;
Cheng, Xirui
;
Chen, Boya
  |  
收藏
  |  
浏览/下载:46/0
  |  
提交时间:2025/06/23
HDAC7
PROTAC
Selectivity
Hematologic malignancies
Non-enzymatic function
Developing novel low-density high-entropy superalloys with high strength and superior creep resistance guided by automated machine learning
期刊论文
OAI收割
ACTA MATERIALIA, 2025, 卷号: 285, 页码: 17
作者:
Li, Yancheng
;
Pang, Jingyu
;
Li, Zhen
;
Wang, Qing
;
Wang, Zhenhua
  |  
收藏
  |  
浏览/下载:2/0
  |  
提交时间:2025/04/27
High-entropy superalloys
gamma/gamma' microstructural stability
Mechanical mechanisms
Deformation mechanisms
Machine learning
A Novel BCC/B2 Structural Nb
38
Ti
35
Al
15
V
6
Cr
4
(TaHfMoW)
2
Refractory High-Entropy Alloy with Excellent Specific Yield Strength-Plasticity Synergy
期刊论文
OAI收割
ACTA METALLURGICA SINICA-ENGLISH LETTERS, 2025, 页码: 11
作者:
Liu, Hongbin
;
Xing, Zhenqiang
;
Yang, Yitong
;
Pang, Jingyu
;
Li, Wen
  |  
收藏
  |  
浏览/下载:3/0
  |  
提交时间:2025/04/27
Refractory high entropy alloy
B2 phase
Microstructure
Mechanical property
Deformation mechanism
Dietary Differentiation Mitigates Interspecific Interference Competition Between Sympatric Pallas's Cats (Otocolobus manul) and Red Foxes (Vulpes vulpes)
期刊论文
OAI收割
ANIMALS, 2025, 卷号: 15, 期号: 9
作者:
Wang, Dong
;
Li, Quanbang
;
Gao, Jingyu
;
Hou, Luyi
;
Zou, Yanjun
  |  
收藏
  |  
浏览/下载:14/0
  |  
提交时间:2025/11/27
coexistence
trophic niche
dietary composition
Pallas's cat (Otocolobus manul)
red fox (Vulpes vulpes)
Sanjiangyuan National Park